| 1 |
Dose- Dependent chronic toxicity screening of Hinokitol in zebrafishes: behavioral and Histological Approach |
Krishnapriya Madhu Varier, Sumathi Thangarajan |
ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH |
Vol 13, Issue 1 |
2020 |
|
| 2 |
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. |
Krishnapriya Madhu Varier, Thangarajan Sumathi |
NEUROTOXICITY RESEARCH |
35(4) |
2019 |
945-954. |
| 3 |
Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring |
Sherin Jacob, Thangarajan Sumathi |
CHEMICO BIOLOGICAL INTERACTIONS |
305 |
2019 |
3-10 |
| 4 |
Hinokitiol and Imperatorin as tyrosine hydroxylase inhibitors: A pilot study to analyze the anti-Parkinsonism potential |
Krishnapriya Madhu Varier, Sumathi Thangarajan |
JOURNAL OF PHARMA RESEARCH |
Vol. 8, Issue 7, |
2019 |
|
| 5 |
Ameliorating effects of Chrysin on Scopolamine induced memory impairment in rats: A pilot study Behavioral, Biochemical and Histological approaches |
Thangarajan Sumathi, Bhagyalakshmi Purushothaman, Akila Murugan. |
International Journal of Pharmacy and Biological Sciences |
Volume 9(2) |
2019 |
1363-1376 |
| 6 |
Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation viaregulation of Bax/Bcl-2 ratio |
Sumathi Thangarajan, Aishwarya Vedagir, Shanmathy Somasundaram, Rathika Sakthimanogaran, Mahalakshmi Murugesan |
NEUROTOXICOLOGY AND TERATOLOGY |
66 |
2018 |
35-45 |
| 7 |
Esculetin Protects Striatal Neurons From 3-Nitropropionic Acid Induced Neurotoxicity By Modulating Behavioural And Biochemical Of Male Wistar Rats. |
Arpita Karandikar, Sumathi Thangarajan |
INTERNATIONAL JOURNAL OF CURRENT ADVANCED RESEARCH |
7 |
2018 |
10518-10522 |
| 8 |
Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington’s disease |
Surekha Ramachandran, Sumathi Thangarajan |
METABOLIC BRAIN DISEASE |
33(5) |
2018 |
1459-1470 |
| 9 |
Esculetin and Glycyrrhizin to Huntington N-terminal fragment |
Arpita Karandikar, Sumathi Thangarajan |
International Journal of Pharmacy and Biological Sciences |
8(1) |
2018 |
564-576 |
| 10 |
Fisetin impedes developmental MeHg neurotoxicity via downregulating ERK1/2 and Caspase 3 mRNA expressions and upregulating Rho A/ Rac1 / Cdc42 m RNA expressions in hippocampus of F1 generation rats |
Sherin Jacob, Sumathi Thangarajan |
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE |
69 |
2018 |
88-96 |
| 11 |
Neuromodulatory effect of cynodon dactylon on cuprizone (CPZ) induced multiple sclerosis in wistar rat copus collusum- A pilot study on Cognitive, Biochemical and histopathological approach. |
Thangarajan Sumathi, Aishwariya Vedagiri, Ramachandran Surekha, Bhagyalakshmi Purushothaman |
INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCES |
8;3 |
2018 |
149-166 |
| 12 |
Methylmercury exposure develops atherosclerotic risk factors in the aorta and programmed cell death in the cerebellum:amelioratve action of Celastrus paniculatus ethanolic extract in male wistar rats. |
Thangarajan Sumathi, Sherin Jacob, Rahul Gopalakrishnan |
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH |
25(30) |
2018 |
30212-30223 |
| 13 |
Quinolinic Acid-Induced Huntington Disease-Like Symptoms Mitigated by Potent Free Radical Scavenger Edaravone-a Pilot Study on Neurobehavioral, Biochemical, and Histological Approach in Male Wistar Rats. |
Thangarajan Sumathi, Aishwariya Vedagiri, Surekha Ramachandran , Bhagyalakshmi Purushothaman |
JOURNAL OF MOLECULAR NEUROSCIENCE |
66(3) |
2018 |
322-341 |
| 14 |
Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington's disease model in rats. |
Sarumani Natarajan Suganya, Thangarajan Sumathi |
METABOLIC BRAIN DISEASE |
32(2) |
2017 |
471-481. |
| 15 |
Comparative analysis of potentiality of Esculin and Hinokitol (β-Thujaplicin) as anti-parkinsonism drugs: a pilot in silico study |
KRISHNAPRIYA MADHU VARIER, SUMATHI THANGARAJAN,ARULVASU CHINNASAMY, GOPALSAMY BALAKRISHNAN, RENJITH PAULOSE |
INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES |
9(1) |
2017 |
108 - 115 |
| 16 |
Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. |
Chandran Anusha, Thangarajan Sumathi, Leena Dennis Joseph |
CHEMICO BIOLOGICAL INTERACTIONS |
1;269 |
2017 |
67-79. |
| 17 |
Protective Activity of Esculetin Against 3-Nitropropionic Acid
Induced Neurotoxicity Via Scavenging Reactive Oxygen Species in
Male Wistar Rats |
Arpita Karandikar, Sumathi Thangarajan |
INTERNATIONAL JOURNAL OF PHARMACOGNOSY AND PHYTOCHEMICAL RESEARCH |
9(5) |
2017 |
722-732 |
| 18 |
Effect of Gestational Intake of Fisetin (3,3',4',7-Tetrahydroxyflavone) on Developmental Methyl Mercury Neurotoxicity in F1 Generation Rats |
Sherin Jacob, Sumathi Thangarajan |
BIOLOGICAL TRACE ELEMENT RESEARCH |
177(2) |
2017 |
297-315. |
| 19 |
Effect of Imperatorin in Neuropathology of Parkinson’s Diseases: An In silico Study |
Krishnapriya Madhu Varier, Sumathi Thangarajan, Arulvasu Chinnasamy |
INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH |
9(8) |
2017 |
599-609. |
| 20 |
Nootropic Activity Of Isorhamnetin In Amyloid Beta 25-35 Induced Cognitive Dysfunction and
its related mRNA Expressions In Alzheimer’s Disease. |
Deivasigamani Asha, Thangarajan Sumathi |
INTERNATIONAL JOURNAL OF PHARMACOGNOSY AND PHYTOCHEMICAL RESEARCH |
8(7) |
2016; |
1191-1199 |
| 21 |
Neuroprotective Effect of Portulaca oleraceae Ethanolic Extract Ameliorates Methylmercury Induced Cognitive Dysfunction and Oxidative Stress in Cerebellum and Cortex of Rat Brain. |
Thangarajan Sumathi, Johnson Christinal |
BIOLOGICAL TRACE ELEMENT RESEARCH |
172(1) |
2016 |
155-65 |
| 22 |
L-theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory
cytokines and oxidative stress in rat brain. |
Thangarajan Sumathi , Deivasigamani Asha 2, Ganesan Nagarajan, Arivazhagan Sreenivas, Rajendran Nivedha |
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY |
42 |
2016 |
99-117 |
| 23 |
Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease. |
Aishwarya Vedagiri, Sumathi Thangarajan |
NEUROPEPTIDES |
58 |
2016 |
111-125 |
| 24 |
Neurotoxic Effects of Gestational Exposure of Methyl Mercury on Different Brain Regions of
F1 Generation; Neurobehavioural, Biochemical and Histological Study During Weaning Period
of Rat. |
INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH |
Sherin J, Sumathi T |
8(2) |
2016 |
83-93 |
| 25 |
Protective Role of Apigenin Against Rotenone Induced Model of Parkinson’s Disease:
Behavioral Study. |
Chandran Anusha, Thangarajan Sumathi |
INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH |
8(2) |
2016 |
79-82 |
| 26 |
Rutin a Dietary Flavonoid Protects Against Altered Neurobehavioral, Membrane Bound Enzymes and Striatal Damage Induced by 3-Nitropropionic Acid in Male Wistar Rats. |
Suganya Sarumani Natarajan,Sumathi Thangarajan, |
INTERNATIONAL JOURNAL OF PHARMACOGNOSY AND PHYTOCHEMICAL RESEARCH |
8(7) |
2016 |
1191-1199 |
| 27 |
A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington's disease-like symptoms in wistar
rats. |
Surekha Ramachandran, Sumathi Thangarajan |
CHEMICO BIOLOGICAL INTERACTIONS |
256 |
2016 |
25-36 |
| 28 |
Chrysin exerts Neuroprotective effects against
3-Nitropropionic acid induced behavioral
despair- Mitochondrial dysfunction and
striatal apoptosis via upregulating Bcl-2 gene
and downregulatingBax-Bad genes in male
wistar
rats. |
Sumathi Thangarajan, Surekha Ramachandran, Priya Krishnamurthy |
BIOMEDICINE & PHARMACOTHERAPY |
84 |
2016 |
514-525 |
| 29 |
An Efficient Encapsulation of Thymoquinone Using Solid Lipid
Nanoparticle for Brain Targeted Drug Delivery: Physicochemical
Characterization, Pharmacokinetics and Bio-Distribution Studies |
Surekha R, Sumathi T |
International Journal of Pharmaceutical and Clinical Research 2016; |
8(12) |
2016 |
1616-1624 |
| 30 |
Enhanced Blood–Brain Barrier Transmigration Using the Novel
Chrysin Embedded Solid Lipid Nanoformulation: A Salient Approach
on Physico-Chemical Characterization, Pharmacokinetics and
Biodistribution Studies |
Aishwarya V, Sumathi T |
International Journal of Pharmaceutical and Clinical Research |
8(12) |
2016 |
1574-1582 |
| 31 |
Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain – histopathological, and biochemical approach |
Thangarajan Sumathi,Chandrasekar Shobana,Mohan Thangarajeswari, Ramakrishnan Usha |
Drug and Chemical Toxicology |
Volume 38 |
2015 |
22-31 |
| 32 |
Preparation, characterization and in-vitro cell viability assay of Chrysin loaded solid lipid nanoparticles as drug delivery system. |
VEDAGIRI AISHWARYA, RAMACHANDRAN SUREKHA AND THANGARAJAN SUMATHI |
INTERNATIONAL JOURNAL OF PHARMA AND BIOSCIENCE |
6(1) |
2015 |
465 - 478 |
| 33 |
Thymoquinone loaded solid lipid nanoparticle: Formulation, characterization and in-vitro cell viability assay |
R. Surekha,Aishwarya Vedagiri,T. Sumathi |
International Journal of Pharma and Bio Sciences |
6(1) |
2015 |
449 - 464 |
| 34 |
Isorhamnetin (IRN) attenuates cognitive dysfunction induced by the intracerebroventricular injection of Amyloid beta (Aβ 25-35) in Sprague Dawley rats. |
D. Asha,T. Sumathi |
Journal of Pharmaceutical Sciences and Research |
7(3) |
2015 |
130 - 136 |
| 35 |
L – Theanine, an aminoacid in tea augments Methylmercury (Global pollutant) induced biochemical, behavioural and histological changes in rat cerebellum |
T. Sumathi, J. Christinal |
International Journal of Pharmacognosy and Phytochemical Research |
7(2) |
2015 |
286 - 293 |
| 36 |
Chrysin, a Natural Flavonoid Attenuates Cognitive Dysfunction and Neuronal Loss Associated with Amyloid β (25-35) - Induced Oxidative Stress: An Experimental Model of Alzheimer's Disease |
Aishwarya V., Sumathi T. |
International Journal of Pharmacognosy and Phytochemical Research |
7(2) |
2015 |
224 - 236 |
| 37 |
Bacopa monniera, A Nootropic herb
alleviates abnormal molecular and immunohistochemical changes evoked by
chronic exposure of Methylmercury in rat cerebellum. |
Johnson Christinal, Thangarajan Sumathi |
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH |
6(8) |
2015 |
3626- 3633 |
| 38 |
Neuroprotective activity of L-theanine on 3-nitropropionic
acid-induced neurotoxicity in rat striatum |
Sumathi Thangarajan, Asha Deivasigamani, Suganya Sarumani Natarajan, Prasanna Krishnan & Sandhya Koombankallil Mohanan |
INTERNATIONAL JOURNAL OF NEUROSCIENCE |
124 |
2014 |
1–12 |
| 39 |
Neuroprotective effects of Apigenin in Human Neuroblastoma
SH-SY5Y cells Against Rotenone toxicity: a pilot study. |
Chandran Anusha, Thangarajan Sumathi, Mayan Rajkumar, Krishnaswamy Kaveri |
DRUG INVENTION TODAY |
6(1) |
2014 |
6-12 |
| 40 |
Neuroprotective potential of Bacopa monniera on hypercholesterolemia induced nephropathy via NO signaling pathway. |
Venkatakrishnan Kamesh, Thangarajan Sumathi |
PHARMACEUTICAL BIOLOGY |
52(10) |
2014 |
1327-34. |
| 41 |
Chronic administration of Methylmercury alters cognitive and mitochondrial dysfunction in rat cerebellum – A novel approach to therapy for Minamata disease by a medhya rasayana drug Bacopa monniera |
J. Christinal, T. Sumathi |
International Journal of Pharma and Bio Sciences |
5(4) |
2014 |
1183-1194 |
| 42 |
Neuroprotective effects of ethanolic seed extract from celastrus paniculatus against Methylmercury – ‘A global pollutant’ induced neurotoxicity in cerebellum of rat. |
THANGARAJAN SUMATHI, JOHNSON CHRISTINAL, BEEMAN NARMATHA DEVI, RAMAYAN CHITRA |
ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH |
7(5) |
2014 |
128 - 135 |
| 43 |
Rutin attenuates 3 – Nitropropionic acid induced behavioural alterations and mitochondrial dysfunction in the striatum of rat brain. |
Sarumani Natarajan Suganya, Thangarajan Sumathi |
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES |
4(1) |
2014 |
1080 - 1092 |
| 44 |
Effect of Bacopa monniera extract on Methylmercury induced behavioral and histopathologiocal changes in rats. |
Johnson Christinal, Thangarajan Sumathi |
BIOLOGICAL TRACE ELEMENT RESEARCH |
155(1) |
2013 |
56-64. |
| 45 |
Molecular docking studies of Bacoside-A, an active component of Bacopa monniera with DJ1 for Anti-Parkinson's drug design |
Shobana Chandrasekar, Sumathi Thangarajan, Sujatha Loganathan, Sureshkannan Sundaram |
BIOMIRROR |
4(09) |
2013 |
1-4 |
| 46 |
Studies on behavioral, biochemical, immunohistochemical and
quantification of dopamine and its metabolites in the striatum of 6-
hydroxy dopamine induced parkinsonism in rats - attenuation by Bacoside A, a major phytoconstituent of Bacopa monniera. |
C. Shobana, T. Sumathi. |
INTERNATIONAL JOURNAL OF APPLIED BIOLOGY AND PHARMACEUTICAL TECHNOLOGY |
4(4) |
2013 |
120-142 |
| 47 |
Oxidative stress in brains of male rats intoxicated with aluminium and neuromodulating effect of Celastruspaniculatusalcoholic seed extract |
T. Sumathi,C. Shobana,V. Mahalakshmi, R. Sureka |
ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH |
5(3) |
2012 |
90-95. |
| 48 |
Protective role of Bacopa monniera on
morphine-induced brain mitochondrial
enzyme activity in rats |
T. Sumathya, S. Govindasamya, |
Fitoterapia |
73 |
2002 |
381-385 |
| 49 |
Effect of Bacopa monniera on liver and kidney toxicity in chronic
use of opioids |
T. Sumathi, S.Niranjali devaraj |
Phytomedicine |
16 |
(2009 |
897–903 |
| 50 |
Hepatoprotective effect of Bacoside-A, a major constituent
of Bacopa monniera Linn |
T. Sumathi.,A.Nongbri |
Phytomedicine |
15 |
(2008) |
901–905 |
| 51 |
Alcoholic extract of ‘Bacopa monniera’ reduces the in vitro effects of
morphine withdrawal in guinea-pig ileum |
Thangarajan Sumathi a, Mohamed Nayeem b, Kedike Balakrishna c, Gopalsamy Veluchamy c, Sivasithamparam Niranjali Devaraj |
Journal of Ethnopharmacology |
82 |
(2002) |
75-81 |
| 52 |
Protective Role of Bacopa monniera on
Morphine Induced Hepatotoxicity in Rats
T. |
T. Sumathy,1 S. Subramanian,1 S. Govindasamy,1* K. Balakrishna2 and G. Veluchamy2 |
|
Phytother. Res. 15, |
(2001) |
643–645 |
| 53 |
Protective Role of Cynodon dactylon in Ameliorating
the Aluminium-Induced Neurotoxicity in Rat Brain
Regions |
Thangarajan Sumathi & Chandrasekar Shobana & Balasubramanian Rathina Kumari & Devarajulu Nisha Nandhini |
|
|
|
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| 54 |
INHIBITORY EFFECT OF BACOPA MONNIERA ON MORPHINE INDUCED PHARMACOLOGICAL EFFECTS IN MICE |
T.SUMATHI, G.VELUSAMY,, K.BALAKRISHNA, S.NIRANJALI DEVARAJ |
|
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|
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| 55 |
Hepatoprotective Activity of Bacopa monniera on D-galactosamine Induced
Hepatotoxicity in Rats |
T. Sumathi* and S. Ramakrishnan |
|
|
|
|
| 56 |
Protective Effect of Bacoside-A against Morphine-
Induced Oxidative Stress in Rats
|
T. SUMATHI*, V. C. NATHIYA AND M. SAKTHIKUMAR |
|
|
|
|
| 57 |
Protective Effect of Bacopa monniera on Methyl Mercury-Induced
Oxidative Stress in Cerebellum of Rats |
Thangarajan Sumathi • Chandrasekar Shobana • Johnson Christinal • Chandran Anusha |
|
|
|
|
| 58 |
Antihypercholesterolemic effect of Bacopa monniera linn. on high
cholesterol diet induced hypercholesterolemia in rats |
Venkatakrishnan Kamesh, Thangarajan Sumathi |
|
|
|
|
| 59 |
Alcoholic Extract of Bacopa monniera Linn. Protects Against
6-Hydroxydopamine-Induced Changes in Behavioral
and Biochemical Aspects: A Pilot Study |
Chandrasekar Shobana • Radhakrishnan Ramesh Kumar • Thangarajan Sumathi |
|
|
|
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| 60 |
EFFECT OF Bacopa monniera LINN. IN ATTENUATING HEPATIC OXIDATIVE STRESS IN HYPERCHOLESTEROLEMIC INDUCED RATS |
VENKATAKRISHNAN KAMESH, THANGARAJAN SUMATHI |
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