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From the Desk of the Vice Chancellor

Greetings!

As the Vice Chancellor of this premier university, I am extremely pleased to share this space to converse with all of you. The University of Madras is a post- sesquicentennial institution which has forged a glorious path for itself and has been the site for significant scientific discoveries as well as the beacon for national and regional societal transformation. It has successfully managed to hold aloft its tradition even while keeping up with the emerging trends. One reason for this is the way in which the university has kept alive its interactions with all the stakeholders.

The COVID 19 pandemic has introduced a ‘new normal’ and its impact is felt in the workings of the university as well. The students have been attending the lectures online. While online learning has the advantage of being anytime and anywhere, it has taken away the peer group interaction and peer learning which are integral aspects of the university experience. We look forward to welcoming you to the campus very soon. Meanwhile, our faculty and administration will continue to bring the best to the virtual classrooms. As students, you need to view the restrictions posed by the pandemic as a temporary deterrent. Your focus should be to gain the competencies to conduct application oriented research in order to evolve as useful citizens of our society.

Our university boasts of faculty with a high degree of knowledge and commitment to offer the best in teaching and research. Given the context of the pandemic, we need to redefine our teaching-learning processes to offer the best pedagogic experience to our students. Similarly, the post-pandemic era demands that we hone the employment potential and entrepreneurial capacity of our learners. This necessitates that we focus on sponsored research in cutting edge areas.

Our administrative staff have been the backbone of the university. While we move towards a transparent and complete e-governance model, we need more support from you. When the teaching-learning process at our university – from admission to certification -- is moving into the digital era, your skills and competencies need to keep pace.

At our university, we are gearing up for the final round of NAAC re-accreditation. This has offered us an opportunity to assess our Strengths, Weaknesses, Opportunities and Challenges. Further, it has made us more determined to reiterate our quality benchmarks in teaching, research and extension activities. We are aware of this responsibility and fully prepared for it because, our university has always encouraged individual thinking within the established frameworks. This is echoed in the words of Tim Burners Lee, who initiated the World Wide Web: “We are forming cells within a global brain and we are excited that we might start to think collectively. What becomes of us still hangs crucially on how we think individually.” Let us unite to make the educational experience at the University of Madras a synergy of the best minds and best thoughts.

Prof.Dr.S.Gowri

Vice-Chancellor
University of Madras

Dr. T.SumathiPh.D.,

Associate Professor
Department of Medical Biochemistry
0

Awards

60

Publications

14

Seminars / Conference

2

Projects

0

Ph.D Awarded

4

Ph.D Present

Publications

Articles (Total Articles: 60)

# Title Author Publisher Volume Year Page(s)
1 Dose- Dependent chronic toxicity screening of Hinokitol in zebrafishes: behavioral and Histological Approach Krishnapriya Madhu Varier, Sumathi Thangarajan ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH Vol 13, Issue 1 2020
2   Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. Krishnapriya Madhu Varier, Thangarajan Sumathi NEUROTOXICITY RESEARCH 35(4) 2019 945-954.
3 Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring  Sherin Jacob, Thangarajan Sumathi CHEMICO BIOLOGICAL INTERACTIONS 305 2019 3-10
4 Hinokitiol and Imperatorin as tyrosine hydroxylase inhibitors: A pilot study to analyze the anti-Parkinsonism potential Krishnapriya Madhu Varier, Sumathi Thangarajan JOURNAL OF PHARMA RESEARCH Vol. 8, Issue 7, 2019
5 Ameliorating effects of Chrysin on Scopolamine induced memory impairment in rats: A pilot study Behavioral, Biochemical and Histological approaches Thangarajan Sumathi, Bhagyalakshmi Purushothaman, Akila Murugan. International Journal of Pharmacy and Biological Sciences Volume 9(2) 2019 1363-1376
6   Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation viaregulation of Bax/Bcl-2 ratio Sumathi Thangarajan, Aishwarya Vedagir, Shanmathy Somasundaram, Rathika Sakthimanogaran, Mahalakshmi Murugesan NEUROTOXICOLOGY AND TERATOLOGY 66 2018 35-45
7 Esculetin Protects Striatal Neurons From 3-Nitropropionic Acid Induced Neurotoxicity By Modulating Behavioural And Biochemical Of Male Wistar Rats. Arpita Karandikar, Sumathi Thangarajan INTERNATIONAL JOURNAL OF CURRENT ADVANCED RESEARCH 7 2018 10518-10522
8 Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington’s disease Surekha Ramachandran, Sumathi Thangarajan METABOLIC BRAIN DISEASE 33(5) 2018 1459-1470
9 Esculetin and Glycyrrhizin to Huntington N-terminal fragment Arpita Karandikar, Sumathi Thangarajan International Journal of Pharmacy and Biological Sciences 8(1) 2018 564-576
10 Fisetin impedes developmental MeHg neurotoxicity via downregulating ERK1/2 and Caspase 3 mRNA expressions and upregulating Rho A/ Rac1 / Cdc42 m RNA expressions in hippocampus of F1 generation rats Sherin Jacob, Sumathi Thangarajan INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 69 2018 88-96
11 Neuromodulatory effect of cynodon dactylon on cuprizone (CPZ) induced multiple sclerosis in wistar rat copus collusum- A pilot study on Cognitive, Biochemical and histopathological approach. Thangarajan Sumathi, Aishwariya Vedagiri, Ramachandran Surekha, Bhagyalakshmi Purushothaman INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCES 8;3 2018 149-166
12 Methylmercury exposure develops atherosclerotic risk factors in the aorta and programmed cell death in the cerebellum:amelioratve action of Celastrus paniculatus ethanolic extract in male wistar rats. Thangarajan Sumathi, Sherin Jacob, Rahul Gopalakrishnan ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 25(30) 2018 30212-30223
13   Quinolinic Acid-Induced Huntington Disease-Like Symptoms Mitigated by Potent Free Radical Scavenger Edaravone-a Pilot Study on Neurobehavioral, Biochemical, and Histological Approach in Male Wistar Rats. Thangarajan Sumathi, Aishwariya Vedagiri, Surekha Ramachandran , Bhagyalakshmi Purushothaman JOURNAL OF MOLECULAR NEUROSCIENCE 66(3) 2018 322-341
14 Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington's disease model in rats. Sarumani Natarajan Suganya, Thangarajan Sumathi METABOLIC BRAIN DISEASE 32(2) 2017 471-481.
15   Comparative analysis of potentiality of Esculin and Hinokitol (β-Thujaplicin) as anti-parkinsonism drugs: a pilot in silico study KRISHNAPRIYA MADHU VARIER, SUMATHI THANGARAJAN,ARULVASU CHINNASAMY, GOPALSAMY BALAKRISHNAN, RENJITH PAULOSE INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 9(1) 2017 108 - 115
16   Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. Chandran Anusha, Thangarajan Sumathi, Leena Dennis Joseph CHEMICO BIOLOGICAL INTERACTIONS 1;269 2017 67-79.
17 Protective Activity of Esculetin Against 3-Nitropropionic Acid Induced Neurotoxicity Via Scavenging Reactive Oxygen Species in Male Wistar Rats Arpita Karandikar, Sumathi Thangarajan INTERNATIONAL JOURNAL OF PHARMACOGNOSY AND PHYTOCHEMICAL RESEARCH 9(5) 2017 722-732
18 Effect of Gestational Intake of Fisetin (3,3',4',7-Tetrahydroxyflavone) on Developmental Methyl Mercury Neurotoxicity in F1 Generation Rats Sherin Jacob, Sumathi Thangarajan BIOLOGICAL TRACE ELEMENT RESEARCH 177(2) 2017 297-315.
19 Effect of Imperatorin in Neuropathology of Parkinson’s Diseases: An In silico Study Krishnapriya Madhu Varier, Sumathi Thangarajan, Arulvasu Chinnasamy INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH 9(8) 2017 599-609.
20 Nootropic Activity Of Isorhamnetin In Amyloid Beta 25-35 Induced Cognitive Dysfunction and its related mRNA Expressions In Alzheimer’s Disease. Deivasigamani Asha, Thangarajan Sumathi INTERNATIONAL JOURNAL OF PHARMACOGNOSY AND PHYTOCHEMICAL RESEARCH 8(7) 2016; 1191-1199
21 Neuroprotective Effect of Portulaca oleraceae Ethanolic Extract Ameliorates Methylmercury Induced Cognitive Dysfunction and Oxidative Stress in Cerebellum and Cortex of Rat Brain. Thangarajan Sumathi, Johnson Christinal BIOLOGICAL TRACE ELEMENT RESEARCH 172(1) 2016 155-65
22 L-theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain. Thangarajan Sumathi , Deivasigamani Asha 2, Ganesan Nagarajan, Arivazhagan Sreenivas, Rajendran Nivedha ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 42 2016 99-117
23 Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease. Aishwarya Vedagiri, Sumathi Thangarajan NEUROPEPTIDES 58 2016 111-125
24   Neurotoxic Effects of Gestational Exposure of Methyl Mercury on Different Brain Regions of F1 Generation; Neurobehavioural, Biochemical and Histological Study During Weaning Period of Rat. INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH Sherin J, Sumathi T 8(2) 2016 83-93
25 Protective Role of Apigenin Against Rotenone Induced Model of Parkinson’s Disease: Behavioral Study. Chandran Anusha, Thangarajan Sumathi INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH 8(2) 2016 79-82
26 Rutin a Dietary Flavonoid Protects Against Altered Neurobehavioral, Membrane Bound Enzymes and Striatal Damage Induced by 3-Nitropropionic Acid in Male Wistar Rats. Suganya Sarumani Natarajan,Sumathi Thangarajan, INTERNATIONAL JOURNAL OF PHARMACOGNOSY AND PHYTOCHEMICAL RESEARCH 8(7) 2016 1191-1199
27 A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington's disease-like symptoms in wistar rats. Surekha Ramachandran, Sumathi Thangarajan CHEMICO BIOLOGICAL INTERACTIONS 256 2016 25-36
28   Chrysin exerts Neuroprotective effects against 3-Nitropropionic acid induced behavioral despair- Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulatingBax-Bad genes in male wistar rats. Sumathi Thangarajan, Surekha Ramachandran, Priya Krishnamurthy BIOMEDICINE & PHARMACOTHERAPY 84 2016 514-525
29 An  Efficient Encapsulation of Thymoquinone Using Solid Lipid Nanoparticle for Brain Targeted Drug Delivery: Physicochemical Characterization, Pharmacokinetics and Bio-Distribution Studies Surekha R, Sumathi T International Journal of Pharmaceutical and Clinical Research 2016; 8(12) 2016 1616-1624
30 Enhanced Blood–Brain Barrier Transmigration Using the Novel Chrysin Embedded Solid Lipid Nanoformulation: A Salient Approach on Physico-Chemical Characterization, Pharmacokinetics and Biodistribution Studies Aishwarya V, Sumathi T International Journal of Pharmaceutical and Clinical Research 8(12) 2016 1574-1582
31 Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain – histopathological, and biochemical approach Thangarajan Sumathi,Chandrasekar Shobana,Mohan Thangarajeswari, Ramakrishnan Usha Drug and Chemical Toxicology Volume 38 2015 22-31
32   Preparation, characterization and in-vitro cell viability assay of Chrysin loaded solid lipid nanoparticles as drug delivery system. VEDAGIRI AISHWARYA, RAMACHANDRAN SUREKHA AND THANGARAJAN SUMATHI INTERNATIONAL JOURNAL OF PHARMA AND BIOSCIENCE 6(1) 2015 465 - 478
33   Thymoquinone loaded solid lipid nanoparticle: Formulation, characterization and in-vitro cell viability assay R. Surekha,Aishwarya Vedagiri,T. Sumathi International Journal of Pharma and Bio Sciences 6(1) 2015 449 - 464
34   Isorhamnetin (IRN) attenuates cognitive dysfunction induced by the intracerebroventricular injection of Amyloid beta (Aβ 25-35) in Sprague Dawley rats. D. Asha,T. Sumathi Journal of Pharmaceutical Sciences and Research 7(3) 2015 130 - 136
35   L – Theanine, an aminoacid in tea augments Methylmercury (Global  pollutant) induced biochemical, behavioural and histological changes in rat cerebellum T. Sumathi, J. Christinal International Journal of Pharmacognosy and Phytochemical Research 7(2) 2015 286 - 293
36 Chrysin, a Natural Flavonoid Attenuates Cognitive Dysfunction and Neuronal Loss Associated with Amyloid β (25-35) - Induced Oxidative Stress: An Experimental Model of Alzheimer's Disease Aishwarya V., Sumathi T. International Journal of Pharmacognosy and Phytochemical Research 7(2) 2015 224 - 236
37 Bacopa monniera, A Nootropic herb alleviates abnormal molecular and immunohistochemical changes evoked by chronic exposure of Methylmercury in rat cerebellum. Johnson Christinal, Thangarajan Sumathi INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 6(8) 2015 3626- 3633
38 Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum Sumathi Thangarajan, Asha Deivasigamani, Suganya Sarumani Natarajan, Prasanna Krishnan & Sandhya Koombankallil Mohanan INTERNATIONAL JOURNAL OF NEUROSCIENCE 124 2014 1–12
39 Neuroprotective effects of Apigenin in Human Neuroblastoma SH-SY5Y cells Against Rotenone toxicity: a pilot study. Chandran Anusha, Thangarajan Sumathi, Mayan Rajkumar, Krishnaswamy Kaveri DRUG INVENTION TODAY 6(1) 2014 6-12
40   Neuroprotective potential of Bacopa monniera on hypercholesterolemia induced nephropathy via NO signaling pathway. Venkatakrishnan Kamesh, Thangarajan Sumathi PHARMACEUTICAL BIOLOGY 52(10) 2014 1327-34.
41 Chronic administration of Methylmercury alters cognitive and mitochondrial dysfunction in rat cerebellum – A novel approach to therapy for Minamata disease by a medhya rasayana drug Bacopa monniera J. Christinal, T. Sumathi International Journal of Pharma and Bio Sciences 5(4) 2014 1183-1194
42 Neuroprotective effects of ethanolic seed extract from celastrus paniculatus against Methylmercury – ‘A global pollutant’ induced neurotoxicity in cerebellum of rat. THANGARAJAN SUMATHI, JOHNSON CHRISTINAL, BEEMAN NARMATHA DEVI, RAMAYAN CHITRA ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH 7(5) 2014 128 - 135
43   Rutin attenuates 3 – Nitropropionic acid induced behavioural alterations and mitochondrial dysfunction in the striatum of rat brain. Sarumani Natarajan Suganya, Thangarajan Sumathi WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 4(1) 2014 1080 - 1092
44 Effect of Bacopa monniera extract on Methylmercury induced behavioral and histopathologiocal changes in rats. Johnson Christinal, Thangarajan Sumathi BIOLOGICAL TRACE ELEMENT RESEARCH 155(1) 2013 56-64.
45 Molecular docking studies of Bacoside-A, an active component of Bacopa monniera with DJ1 for Anti-Parkinson's drug design Shobana Chandrasekar, Sumathi Thangarajan, Sujatha Loganathan, Sureshkannan Sundaram BIOMIRROR 4(09) 2013 1-4
46 Studies on behavioral, biochemical, immunohistochemical and quantification of dopamine and its metabolites in the striatum of 6- hydroxy dopamine induced parkinsonism in rats - attenuation by Bacoside A, a major phytoconstituent of Bacopa monniera. C. Shobana, T. Sumathi. INTERNATIONAL JOURNAL OF APPLIED BIOLOGY AND PHARMACEUTICAL TECHNOLOGY 4(4) 2013 120-142
47 Oxidative stress in brains of male rats intoxicated with aluminium and neuromodulating effect of Celastruspaniculatusalcoholic seed extract T. Sumathi,C. Shobana,V. Mahalakshmi, R. Sureka ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH 5(3) 2012 90-95.
48   Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats T. Sumathya, S. Govindasamya, Fitoterapia 73 2002 381-385
49 Effect of Bacopa monniera on liver and kidney toxicity  in  chronic use of  opioids T. Sumathi, S.Niranjali devaraj Phytomedicine 16 (2009 897–903
50   Hepatoprotective effect of Bacoside-A, a major constituent of Bacopa monniera Linn T. Sumathi.,A.Nongbri Phytomedicine 15 (2008) 901–905
51   Alcoholic extract of ‘Bacopa monniera’ reduces the in vitro effects of morphine withdrawal in guinea-pig ileum Thangarajan Sumathi a, Mohamed Nayeem b, Kedike Balakrishna c, Gopalsamy Veluchamy c, Sivasithamparam Niranjali Devaraj Journal of Ethnopharmacology 82 (2002) 75-81
52   Protective Role of Bacopa monniera on Morphine Induced Hepatotoxicity in Rats T. T. Sumathy,1 S. Subramanian,1 S. Govindasamy,1* K. Balakrishna2 and G. Veluchamy2 Phytother. Res. 15, (2001) 643–645
53   Protective Role of Cynodon dactylon in Ameliorating the Aluminium-Induced Neurotoxicity in Rat Brain Regions Thangarajan Sumathi & Chandrasekar Shobana & Balasubramanian Rathina Kumari & Devarajulu Nisha Nandhini
54 INHIBITORY EFFECT OF BACOPA MONNIERA ON MORPHINE INDUCED PHARMACOLOGICAL EFFECTS  IN MICE T.SUMATHI, G.VELUSAMY,, K.BALAKRISHNA, S.NIRANJALI DEVARAJ
55   Hepatoprotective Activity of Bacopa monniera on D-galactosamine Induced Hepatotoxicity in Rats T. Sumathi* and S. Ramakrishnan
56   Protective Effect of Bacoside-A against Morphine- Induced Oxidative Stress in Rats   T. SUMATHI*, V. C. NATHIYA AND M. SAKTHIKUMAR
57   Protective Effect of Bacopa monniera on Methyl Mercury-Induced Oxidative Stress in Cerebellum of  Rats Thangarajan Sumathi • Chandrasekar Shobana • Johnson Christinal • Chandran Anusha
58   Antihypercholesterolemic effect of Bacopa monniera linn. on high cholesterol diet induced hypercholesterolemia in rats Venkatakrishnan Kamesh, Thangarajan Sumathi
59   Alcoholic Extract of Bacopa monniera Linn. Protects Against 6-Hydroxydopamine-Induced Changes in Behavioral and Biochemical Aspects: A Pilot Study Chandrasekar Shobana • Radhakrishnan Ramesh Kumar • Thangarajan Sumathi
60   EFFECT OF Bacopa monniera LINN. IN ATTENUATING HEPATIC OXIDATIVE STRESS IN HYPERCHOLESTEROLEMIC INDUCED RATS VENKATAKRISHNAN KAMESH, THANGARAJAN SUMATHI
// FLASH NEWS //
  • University of Madras attains category - 1 status from UGC |  NIRF Ranking - Ranked 39 in University Category 2024 |  University of Madras has been graded A++ in the NAAC Assessment

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