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From the Desk of the Vice Chancellor

Greetings!

As the Vice Chancellor of this premier university, I am extremely pleased to share this space to converse with all of you. The University of Madras is a post- sesquicentennial institution which has forged a glorious path for itself and has been the site for significant scientific discoveries as well as the beacon for national and regional societal transformation. It has successfully managed to hold aloft its tradition even while keeping up with the emerging trends. One reason for this is the way in which the university has kept alive its interactions with all the stakeholders.

The COVID 19 pandemic has introduced a ‘new normal’ and its impact is felt in the workings of the university as well. The students have been attending the lectures online. While online learning has the advantage of being anytime and anywhere, it has taken away the peer group interaction and peer learning which are integral aspects of the university experience. We look forward to welcoming you to the campus very soon. Meanwhile, our faculty and administration will continue to bring the best to the virtual classrooms. As students, you need to view the restrictions posed by the pandemic as a temporary deterrent. Your focus should be to gain the competencies to conduct application oriented research in order to evolve as useful citizens of our society.

Our university boasts of faculty with a high degree of knowledge and commitment to offer the best in teaching and research. Given the context of the pandemic, we need to redefine our teaching-learning processes to offer the best pedagogic experience to our students. Similarly, the post-pandemic era demands that we hone the employment potential and entrepreneurial capacity of our learners. This necessitates that we focus on sponsored research in cutting edge areas.

Our administrative staff have been the backbone of the university. While we move towards a transparent and complete e-governance model, we need more support from you. When the teaching-learning process at our university – from admission to certification -- is moving into the digital era, your skills and competencies need to keep pace.

At our university, we are gearing up for the final round of NAAC re-accreditation. This has offered us an opportunity to assess our Strengths, Weaknesses, Opportunities and Challenges. Further, it has made us more determined to reiterate our quality benchmarks in teaching, research and extension activities. We are aware of this responsibility and fully prepared for it because, our university has always encouraged individual thinking within the established frameworks. This is echoed in the words of Tim Burners Lee, who initiated the World Wide Web: “We are forming cells within a global brain and we are excited that we might start to think collectively. What becomes of us still hangs crucially on how we think individually.” Let us unite to make the educational experience at the University of Madras a synergy of the best minds and best thoughts.

Prof.Dr.S.Gowri

Vice-Chancellor
University of Madras

A. K. MunirajanM.Sc., M.Phil., Ph.D.

Professor and Head
Department of Genetics
19

Awards

56

Publications

37

Seminars / Conference

17

Projects

9

Ph.D Awarded

1

Ph.D Present

Publications

Books (Total Books: 1)

# Title Author Publisher Volume Year Page(s)
1 Reactive Oxygen Species and Cancer Stem Cells: Molecular Interactions and Their Implications in Cancer.  2022 Sep 29 (pp. 2227-2268). Singapore: Springer Nature Singapore. Chengizkhan G, Sukumar K, Kunnumakkara AB, Queimado L, Munirajan AK, Bhaskaran RS, Kumaran RI, Ramachandran I InHandbook of Oxidative Stress in Cancer: Therapeutic Aspects, Springer Nature Singapore. Sep 29 2022 2227-2268

Journals (Total Journals: 55)

# Title Author Publisher Volume Year Page(s)
1 APOBEC mediated mutagenesis drives genomic heterogeneity in endometriosis.   Revathidevi S, Nakaoka H, Suda K, Fujito N, Munirajan AK, Yoshihara K, Enomoto T, Inoue I. J Hum Genet. 2022 67(6) 323-329 - PMID: 35017684.
2 Super enhancer loci of EGFR regulate EGFR variant 8 through enhancer RNA and strongly associate with survival in HNSCCs.  https://doi.org/10.1007/s00438-023-02089-z PMID: 38236481 Chakkarappan SR, Umadharshini KV, Dhamodharan S, Rose MM, Gopu G, Murugan AK, Inoue I, Munirajan AK. Molecular Genetics and Genomics 299(1) 2024 3
3 Impact of Genetic Polymorphisms in NF-?B2 and TRAF3 Genes on Response to Bortezomib-Based Therapy in Multiple Myeloma Patients.     Sood N, Hamide A, Dubashi B, Nisha Y, Mathaiyan J, Munirajan AK, Ganesn P, Kayal S. Asian Pac J Cancer Prev. 25(3): 2024 829-837
4 SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients. Bharath G, Vishnuprabu DP, Preethi L, Nagappan AS, Dhianeshwaran Isravanya RT, Bhaskar LV, Swaminathan N, Munirajan AK. Pharmacogenomics 12 2022 683-694
5 AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells. Revathidevi, S. Hosomichi, K. Natsume, T. Nakaoka, H. Fujito, N.T. Akatsuka, H. Sato, T. Munirajan, A.K. Inoue, I Int. J. Mol. Sci. 23 2022 11124
6 Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders Allu PKR, Kiranmayi M, Mukherjee SD, Chirasani VR, Garg R, Vishnuprabu D, Ravi S, Subramanian L, Sahu BS, Iyer DR, Maghajothi S, Sharma S, Ravi MS, Khullar M, Munirajan AK, Gayen JR, Senapati S, Mullasari AS, Mohan V, Radha V, Naga Prasad SV, Mahapatra NR. Diabetes 71(3) 2022 538-553 - doi: 10.2337/db21-0289. PMID: 34862200.
7 Linc-ROR genetic variants are associated with the advanced disease in oral squamous cell carcinoma.    Rose MM, Dhamodharan S, Bharath G, Murali K, Subbiah S, Bhaskar LV, Murugan AK, Munirajan AK. Arch Oral Biol. 139 2022 105428 - PMID: 35461069.
8 Gliomas: Genetic alterations, mechanisms of metastasis, recurrence, drug resistance, and recent trends in molecular therapeutic options. Kannan S, Murugan AK, Balasubramanian S, Munirajan AK, Alzahrani AS. Biochem Pharmacol. 201 2022 115090 - PMID: 35577014
9 High incidence of PI3K pathway gene mutations in South Indian cervical cancers.    Rose MM, Dhamodharan S, Revathidevi S, Chakkarappan SR, Jagadeesan MG, Subbiah S, Nakaoka H, Inoue I, Murugan AK, Munirajan AK. Cancer Genet. 264-265 2022 100-108 - PMID: 35568000.
10 Deep sequencing unveil altered cardiac miRNome in congenital heart disease.   Ramachandran V, Bhagavatheeswaran S, Shanmugam S, Vasudevan M, Ragunathan M, Cherian KM, Munirajan AK, Ravi S, Balakrishnan A. Mol Genet Genomics. doi: 10.1007/s00438-022-01908-z. Epub ahead of print. 2022 PMID: 35668131
11 Genetic variant rs 10251977 (G> A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D.    Dhamodharan S, Rose MM, Chakkarappan SR, Umadharshini KV, Arulmurugan R, Subbiah S, Inoue I, Munirajan AK. Scientific reports. 11(1): 2021 1-4.
12 Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women Vilvanathan Vinothkumar Kanagaraj Arun Ganesan Arunkumar Sundaramoorthy Revathidevi Rajendren Ramani Lakkakula V.K.S. Bhaskar Avaniyapuram Kannan Murugan Arasambattu Kannan Munirajan Molecular and Clinical Oncology https://doi.org/10.3892/mco.2020.2003 2020
13 Akt in cancer: Mediator and more. Revathidevi S, Munirajan AK Semin Cancer Biol. S1044-579X(18)30062-2 2019 doi: 10.1016/j.semcancer.2019.06.002.
14 Long noncoding RNAs: emerging players in thyroid cancer pathogenesis. Murugan AK, Munirajan AK, Alzahrani AS. Endocr Relat Cancer. 25(2) 2018 R59-R82. doi: 10.1530/ERC-17-0188
15 Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma.   Arunkumar G, Deva Magendhra Rao AK, Manikandan M, Prasanna Srinivasa Rao H, Subbiah S, Ilangovan R, Murugan AK, Munirajan AK. Oncol Lett. 15(1) 2018 649-657. doi: 10.3892/ol.2017.7296
16 Replication of GWAS identified miR-137 and its target gene polymorphisms in Schizophrenia of South Indian population and meta-analysis with Psychiatric Genomics Consortium Sudesh R, Thalamuthu A, John S, Thara R, Mowry B, Munirajan AK. Schizophr Res. 199 2018 189-194. doi: 10.1016/j.schres.2018.03.028
17 LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors. Arunkumar G, Anand S, Raksha P, Dhamodharan S, Prasanna Srinivasa Rao H, Subbiah S, Murugan AK, Munirajan AK. Sci Rep. 4;8(1) 2018 7018. doi: 10.1038/s41598-018-25451-3
18 Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin. Arunkumar G, Vishnuprabu D, Nupur B, Vidyasagaran T, Murugan AK, Munirajan AK. Drug Discov Ther. 11(4):198-205. 2017 11(4):198-205. doi: 10.5582/ddt.2017.01031. PubMed PMID: 28867752.
19 Absence of the frequently reported PIK3CA, CASP8, and NOTCH1 mutations in South Indian oral cancers. Arunkumar G, Murugan AK, Nagarajan M, Ajay C, Rajaraman R, Munirajan AK. Oral Dis. 23(5): 2017 669-673
20 Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population. Sudesh R, Priyadarshini T, Preeti R, John S, Thara R, Mowry B, Munirajan AK. Neurosci Lett. 649: 2017 107-111
21 Long non-coding RNA CCAT1 is overexpressed in oral squamous cell carcinomas and predicts poor prognosis Arunkumar G, Murugan AK, Prasanna Srinivasa Rao H, Subbiah S, Rajaraman R, Munirajan AK. Biomed Rep. 6(4): 2017 455-462
22 Expression profiling of long non-coding RNA identifies linc-RoR as a prognostic biomarker in oral cancer. Arunkumar G, Deva Magendhra Rao AK, Manikandan M, Arun K, Vinothkumar V, Revathidevi S, Rajkumar KS, Rajaraman R, Munirajan AK. Tumour Biol. 39(4) 2017 1010428317698366. doi: 10.1177/1010428317698366
23 Screening for the 3'UTR Polymorphism of the PXR Gene in South Indian Breast Cancer Patients and its Potential Role in Pharmacogenomics.   Revathidevi S, Sudesh R, Vaishnavi V, Kaliyanasundaram M, MaryHelen KG, Asian Pac J Cancer Prev. 17(8): 2016 3971-7.
24 Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway Kiranmayi M, Chirasani VR, Allu PK, Subramanian L, Martelli EE, Sahu BS, Vishnuprabu D, Kumaragurubaran R, Sharma S, Bodhini D, Dixit M, Munirajan AK, Khullar M, Radha V, Mohan V, Mullasari AS, Naga Prasad SV, Senapati S, Mahapatra NR. Hypertension HYPERTENSIONAHA.116.06568. [Epub ahead of print] PubMed PMID: 27324226. 2016 1-15
25 Analysis of APOBEC3A/3B germline deletion polymorphism in breast, cervical and oral cancers from South India and its impact on miRNA regulation. Revathidevi S, Manikandan M, Rao AK, Vinothkumar V, Arunkumar G, Rajkumar KS, Ramani R, Rajaraman R, Ajay C, Munirajan AK Tumour Biol. 37(9) 2016 11983-11990.
26 Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism. Manikandan M, Deva Magendhra Rao AK, Arunkumar G, Manickavasagam M, Rajkumar KS, Rajaraman R, Munirajan AK. Mol Cancer. 15 2016 28
27 Genotyping and meta-analysis of KIF6 Trp719Arg polymorphism in South Indian Coronary Artery Disease patients: A case-control study Vishnuprabu D, Geetha S, Bhaskar LV, Mahapatra NR, Munirajan AK. Meta Gene 5 2015 129-34
28 MicroRNAs: Modulators of the Ras Oncogenes in Oral Cancer. J Cell Physiol. Murugan AK, Munirajan AK, Alzahrani AS. J Cell Physiol. doi: 10.1002/jcp.25269 2015
29 TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas. Vinothkumar V, Arunkumar G, Revathidevi S, Arun K, Manikandan M, Rao AK, Rajkumar KS, Ajay C, Rajaraman R, Ramani R, Murugan AK, Munirajan AK. Tumour Biol. [Epub ahead of print] PubMed PMID: 26700669 2015
30 Mining the 3'UTR of Autism-implicated Genes for SNPs Perturbing MicroRNA Regulation. Vaishnavi V, Manikandan M, Munirajan AK enomics Proteomics Bioinformatics 2 2014 92-104
31 Expression and integrity of dermatopontin in chronic cutaneous wounds: a crucial factor in impaired wound healing Krishnaswamy VR, Manikandan M, Munirajan AK, Vijayaraghavan D, Korrapati PS. Cell Tissue Res. 358 2014 833-841
32 Absence of the TP53 poly-A signal sequence variant rs78378222 in oral, cervical and breast cancers in South India Rao AK, Vinothkumar V, Revathidevi S, Arunkumar G, Manikandan M, Arun K, Rajkumar KS, Ramani R, Ramamurthy R, Munirajan AK Asian Pac J Cancer Prev 15 2014 9555-9556
33 Altered levels of miR-21, miR-125b-2*, miR-138, miR-155, miR-184, and miR-205 in oral squamous cell carcinoma and association with clinicopathological characteristics Manikandan M, Deva Magendhra Rao AK, Rajkumar KS, Rajaraman R, Munirajan AK. J Oral Pathol Med. doi: 10.1111/jop.12300 2014 doi: 10.1111/jop.12300
34 Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Oncogenes: Implications in Cancer and Pharmacogenomics Manikandan M, Munirajan AK. OMICS 18(2) 2014 142-154
35 Structural and functional studies on urease from pigeon pea (Cajanus  cajan) Balasubramanian A, Durairajpandian V, Elumalai S, Mathivanan N, Munirajan AK, Ponnuraj K Int J Biol Macromol doi:pii: S0141-8130(13)00238-9. 10.1016/j.ijbiomac.2013.04.055 2013
36 Insights on the Functional Impact of MicroRNAs Present in Autism-Associated Copy Number Variants.   Vaishnavi V, Manikandan M, Tiwary BK, Munirajan AK. PLoS One 8(2) 2013 e56781
37 Functional PstI/RsaI Polymorphisms in the CYP2E1 Gene among South Indian Populations.  Lakkakula S, Maram R, Munirajan AK, Pathapati RM, Visveswara SB, Lakkakula BV. Asian Pac J Cancer Prev 14(1) 2013 179-182
38 Genetic deregulation of the PIK3CA oncogene in oral cancer Murugan AK, Munirajan AK, Tsuchida N Cancer Lett. doi:pii: S0304-3835(13)00325-X. 10.1016/j.canlet.2013.04.005 2013 Epub ahead of print
39 A novel splice site and two known mutations of androgen receptor gene in sex-reversed XY phenotype Vasu VR, Saranya B, Jayashankar M, Munirajan AK, Santhiya ST Genet Test Mol Biomarkers 16 2012 749-55
40 Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach Manikandan M, Raksha G, Munirajan AK Cancer Inform 11 2012 157-71
41 Ras oncogenes in oral cancer: The past 20 years Murugan AK, Munirajan AK, Tsuchida N. Oral Oncol 48(5) 2012 383-92
42 Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer Murugan AK, Hong NT, Cuc TT, Hung NC, Munirajan AK, Ikeda MA, Tsuchida N Oral Oncol. 45(10) 2009 e161-6
43 KIF1Bbeta functions as a haploinsufficient tumour suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death Munirajan AK, Ando K, Mukai A, Takahashi M, Suenaga Y, Ohira M, Koda T, Hirota T, Ozaki T, Nakagawara A J Biol Chem 283(36) 2008 24426-34
44 Promoter hypermethylation analysis in myelodysplastic syndromes: diagnostic & prognostic implication Solomon PR, Munirajan AK, Tsuchida N, Muthukumarasamy K, Rathinavel A, Selvam GS, Shanmugam G Indian J Med Res 127(1) 2008 52-7
45 Oncogenic mutations ofthe PIK3CA gene in head and neck squamous cell carcinomas Murugan AK, Hong NT, Fukui Y, Munirajan AK, Tsuchida N Int J Oncol. 32(1) 2008 101-11
46 FHIT gene mutations and single nucleotide polymorphism in Indian oral and cervical squamous cell carcinomas Kannan K, Munirajan AK, Bhuvarahamurthy V, Mohanprasad BK, Shankar P, Tsuchida N, Shanmugam G Oral Oncol. 36(2) 2000 189-93
47 The p16INK4alpha/p19ARF gene mutationsare infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas Kannan K, Munirajan AK, Krishnamurthy J, Bhuvarahamurthy V, Mohanprasad BK, Panishankar KH, Tsuchida N, Shanmugam G Int J Oncol. 16(3) 2000 585-90
48 Low incidence of p53 mutations in betel quid and tobacco chewing-associated oral squamous carcinoma from India. Kannan K, Munirajan AK, Krishnamurthy J, Bhuvarahamurthy V, Mohanprasad BK, Panishankar KH, Tsuchida N, Shanmugam G Int J Oncol. 15(6) 1999 1133-6
49 Infrequent genetic alterations of p53, p16 genes and polymorphism in fhit gene in Indian myelodysplastic syndrome. Kannan K, Tharu R, Gopinath PM, Bharadwaj TP, Munirajan AK, Tsuchida N, Shanmugam G Oncol Res. 11(2) 1999 101-4
50 Detection of a rarepoint mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer. Munirajan AK, Mohanprasad BK, Shanmugam G, Tsuchida N Int J Oncol. 13(5) 1998 971-4
51 The status of human papillomavirus and tumor suppressor genes p53 and p16 in carcinomas of uterine cervix from India. Munirajan AK, Kannan K, Bhuvarahamurthy V, Ishida I, Fujinaga K, Tsuchida N, Shanmugam G Gynecol Oncol. 69(3) 1998 205-9
52 p53 mutations and their role in tumorigenesis Tsuchida N, Munirajan AK Tanpakushitsu Kakusan Koso. 42(10 Suppl) 1997 1567-75
53 p53 gene mutations in oral carcinomas from India. Munirajan AK, Tutsumi-Ishii Y, Mohanprasad BK, Hirano Y, Munakata N, Shanmugam G, Tsuchida N Int J Cancer. 66(3) 1996 297-300
54 Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer. Arun K, Arunkumar G, Bennet D, Chandramohan SM, Murugan AK, Munirajan AK. Oncotarget. 9(26) 2018 18386-18399. doi: 10.18632/oncotarget.24841
55 Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study. Manikandan M, Deva Magendhra Rao AK, Arunkumar G, Rajkumar KS, Rajaraman R, Munirajan AK. Asian Pac J Cancer Prev. 16 2015 7619-25
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