1 |
NUAKs facilitate mTOR-mediated NSCLC proliferation and metastasis by modulating glucose metabolism and inhibiting p53 activity |
Yesupogu Moorthy Babu J, Manoharan R. |
Biochim Biophys Acta Mol Cell Res. |
17 |
2025 |
119922 |
2 |
Salt-inducible kinases (SIKs) in cancer: mechanisms of action and therapeutic prospects. |
Ravi manoharan |
Drug Discov Today |
30 |
2024 |
104279 |
3 |
Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion |
Nandhini S, Ranjani M, Thiruppathi G, Jaithanya YM, Kalaiarasi G, Ravi M, Prabusankar G, Malecki JG, Sundararaj P, Prabhakaran R |
J Inorg Biochem |
8;257 |
2024 |
112593 |
4 |
Effect of ruthenium(II) complexes on MDA-MB-231 cells and lifespan/tumor growth in gld-1mutant, Daf-16 TF and stress productive genes: A perspective study |
Nandhini S, Thiruppathi G, Ranjani M, Pushmann H, Ravi M, Sundararaj P, Prabhakaran R. |
J Inorg Biochem |
28;257 |
2024 |
112580 |
5 |
Radical dendrimer: bis-indolyl polyurethane dendrimers containing TEMPO radicals for inhibition of cancer cell growth |
Bargathulla, I., Mohamad Ali, B., Skadon, W. A., Nasar, A. S., & Manoharan, R |
Journal of Macromolecular Science, Part A |
61(7) |
2024 |
483–492 |
6 |
NUAKs promote mTOR/c-Myc-induced glucose and glutamine reprogramming for cell growth and metastasis in breast cancer cells. |
Skadon, W. A., & Manoharan, R. |
Biochim Biophys Acta Mol Basis Dis. |
1 |
2024 |
|
7 |
Diosgenin derivatives developed from Pd(ii) catalysed dehydrogenative coupling exert an effect on breast cancer cells by abrogating their growth and facilitating apoptosis via regulating the AKT1 pathway |
S. Dharani, G. Kalaiarasi, M. Ravi, N. Sathan Raj, Vincent M. Lynch, R. Prabhakaran. |
Dalton Trans |
RSC |
2022 |
|
8 |
MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway |
Sathan Raj Natarajan, Lavanya Ponnusamy, Ravi Manoharan |
Biochim Biophys Acta Mol Cell Res |
1869(3) |
2022 |
119242 |
9 |
MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways |
Lavanya Ponnusamy,Sathan Raj Natarajan,Ravi Manoharan |
Journal of Cellular Biochemistry |
1 |
2022 |
|
10 |
Distinctive role of SIK1 and SIK3 isoforms in aerobic glycolysis and cell growth of breast cancer through the regulation of p53 and mTOR signaling pathways |
Lavanya Ponnusamy and Ravi Manoharan |
BBA- Molecular cell Resarch |
118975 |
2021 |
1 |
11 |
DAXX ameliorates metabolic dysfunction in mice with diet-induced obesity by activating the AMP-activated protein kinase-related kinase
MPK38/MELK
Hyun-A Seong and Ravi Manoharan contributed equally to this work |
Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha |
Biochemical and Biophysical Research Communications |
1;572 |
2021 |
164-170 |
12 |
Palladium-mediated C–O bond activation of benzopyrone in 4-oxo-4H-chromone-3-carbaldehyde-4(N)-substituted thiosemicarbazone: synthesis, structure, nucleic acid/albumin interaction, DNA cleavage, antioxidant and cytotoxic studies |
A. Shanmugapriya, G. Kalaiarasi, M. Ravi, H. A. Sparkes, P. Kalaivanid and R. Prabhakaran |
New Journal of Chemistry |
45 |
2021 |
20227-20240 |
13 |
MELK/MPK38 in cancer: from mechanistic aspects to therapeutic strategies. |
Karthik Thangaraj, Lavanya Ponnusamy, Sathan Raj Natarajan, and Ravi Manoharan |
Drug Discov Today |
25 |
2020 |
30386 |
14 |
Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway. |
Lavanya Ponnusamy, Gugan Kothandan, and Ravi Manoharan |
Biochim Biophys Acta Mol Basis Dis |
1866 |
2020 |
165897 |
15 |
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. |
Lavanya Ponnusamy, Sathan Raj Natarajan, Karthik Thangaraj, and Ravi Manoharan |
Biochim Biophys Acta Rev Cancer |
1874 |
2020 |
188379 |
16 |
Understanding the dual mechanism of bioactive peptides targeting the enzymes involved in Renin Angiotensin System (RAS): An in-silico approach. |
Seshan G, Kanagasabai S, Jayanti B, Shantkriti S, Jaimohan S M , Ravi M, Sowmya R, Sekar K, and Gugan K. |
J Biomol Struct Dyn. |
38 |
2020 |
5044-5061 |
17 |
Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. |
Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. |
Cell Death Dis. |
9 |
2018 |
471 |
18 |
Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development. |
Ravi Manoharan, Hyun-A Seong, and Hyunjung Ha. |
Oxid Med Cell Longev. |
1 |
2018 |
5241524 |
19 |
Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways. |
Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. |
Sci Rep |
7 |
2017 |
42502 |
20 |
Coordinate Activation of Redox-Dependent ASK1/TGF-β Signaling by a Multiprotein Complex (MPK38, ASK1, SMADs, ZPR9, and TRX) Improves Glucose and Lipid Metabolism in Mice. |
Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. |
Antioxid Redox Signal. |
24 |
2016 |
434-52 |
21 |
A crucial role for the phosphorylation of STRAP at Ser (188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways. |
Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. |
Cell Cycle. |
13 |
2014 |
3357-74 |
22 |
Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner. |
Ravi Manoharan, Hyun-A Seong, and Hyunjung Ha. |
Free Radic Biol Med. |
63 |
2013 |
313-24 |
23 |
PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity. |
Hyun-A Seong , Haiyoung Jung, Ravi Manoharan, and Hyunjung Ha. |
J Biol Chem. |
287 |
2012 |
20811-22 |
24 |
Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein. |
Hyun-A Seong , Haiyoung Jung, Ravi Manoharan, and Hyunjung Ha. |
J Biol Chem. |
286 |
2011 |
31123-35 |
25 |
B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction. |
Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha Ha. |
J Biol Chem. |
286 |
2011 |
7439-56 |
26 |
Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. |
Haiyoung Jung, Hyun-A Seong, Ravi Manoharan, and Hyunjung Ha. |
J Biol Chem. |
285 |
2010 |
54-70 |