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From the Desk of the Vice Chancellor

Greetings!

As the Vice Chancellor of this premier university, I am extremely pleased to share this space to converse with all of you. The University of Madras is a post- sesquicentennial institution which has forged a glorious path for itself and has been the site for significant scientific discoveries as well as the beacon for national and regional societal transformation. It has successfully managed to hold aloft its tradition even while keeping up with the emerging trends. One reason for this is the way in which the university has kept alive its interactions with all the stakeholders.

The COVID 19 pandemic has introduced a ‘new normal’ and its impact is felt in the workings of the university as well. The students have been attending the lectures online. While online learning has the advantage of being anytime and anywhere, it has taken away the peer group interaction and peer learning which are integral aspects of the university experience. We look forward to welcoming you to the campus very soon. Meanwhile, our faculty and administration will continue to bring the best to the virtual classrooms. As students, you need to view the restrictions posed by the pandemic as a temporary deterrent. Your focus should be to gain the competencies to conduct application oriented research in order to evolve as useful citizens of our society.

Our university boasts of faculty with a high degree of knowledge and commitment to offer the best in teaching and research. Given the context of the pandemic, we need to redefine our teaching-learning processes to offer the best pedagogic experience to our students. Similarly, the post-pandemic era demands that we hone the employment potential and entrepreneurial capacity of our learners. This necessitates that we focus on sponsored research in cutting edge areas.

Our administrative staff have been the backbone of the university. While we move towards a transparent and complete e-governance model, we need more support from you. When the teaching-learning process at our university – from admission to certification -- is moving into the digital era, your skills and competencies need to keep pace.

At our university, we are gearing up for the final round of NAAC re-accreditation. This has offered us an opportunity to assess our Strengths, Weaknesses, Opportunities and Challenges. Further, it has made us more determined to reiterate our quality benchmarks in teaching, research and extension activities. We are aware of this responsibility and fully prepared for it because, our university has always encouraged individual thinking within the established frameworks. This is echoed in the words of Tim Burners Lee, who initiated the World Wide Web: “We are forming cells within a global brain and we are excited that we might start to think collectively. What becomes of us still hangs crucially on how we think individually.” Let us unite to make the educational experience at the University of Madras a synergy of the best minds and best thoughts.

Prof.Dr.S.Gowri

Vice-Chancellor
University of Madras

Dr. M. RaviPh.D

Assistant Professor
Department of Biochemistry
0

Awards

26

Publications

27

Seminars / Conference

5

Projects

0

Ph.D Awarded

3

Ph.D Present

Publications

Articles (Total Articles: 26)

# Title Author Publisher Volume Year Page(s)
1  NUAKs facilitate mTOR-mediated NSCLC proliferation and metastasis by modulating glucose metabolism and inhibiting p53 activity Yesupogu Moorthy Babu J, Manoharan R. Biochim Biophys Acta Mol Cell Res. 17 2025 119922
2 Salt-inducible kinases (SIKs) in cancer: mechanisms of action and therapeutic prospects. Ravi manoharan Drug Discov Today 30 2024 104279
3 Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion Nandhini S, Ranjani M, Thiruppathi G, Jaithanya YM, Kalaiarasi G, Ravi M, Prabusankar G, Malecki JG, Sundararaj P, Prabhakaran R J Inorg Biochem 8;257 2024 112593
4 Effect of ruthenium(II) complexes on MDA-MB-231 cells and lifespan/tumor growth in gld-1mutant, Daf-16 TF and stress productive genes: A perspective study Nandhini S, Thiruppathi G, Ranjani M, Pushmann H, Ravi M, Sundararaj P, Prabhakaran R. J Inorg Biochem 28;257 2024 112580
5 Radical dendrimer: bis-indolyl polyurethane dendrimers containing TEMPO radicals for inhibition of cancer cell growth Bargathulla, I., Mohamad Ali, B., Skadon, W. A., Nasar, A. S., & Manoharan, R Journal of Macromolecular Science, Part A 61(7) 2024 483–492
6     NUAKs promote mTOR/c-Myc-induced glucose and glutamine reprogramming for cell growth and metastasis in breast cancer cells.  Skadon, W. A., & Manoharan, R. Biochim Biophys Acta Mol Basis Dis. 1 2024
7 Diosgenin derivatives developed from Pd(ii) catalysed dehydrogenative coupling exert an effect on breast cancer cells by abrogating their growth and facilitating apoptosis via regulating the AKT1 pathway S. Dharani, G. Kalaiarasi, M. Ravi, N. Sathan Raj, Vincent M. Lynch, R. Prabhakaran. Dalton Trans RSC 2022
8 MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway Sathan Raj Natarajan, Lavanya Ponnusamy, Ravi Manoharan Biochim Biophys Acta Mol Cell Res 1869(3) 2022 119242
9 MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways Lavanya Ponnusamy,Sathan Raj Natarajan,Ravi Manoharan Journal of Cellular Biochemistry 1 2022
10 Distinctive role of SIK1 and SIK3 isoforms in aerobic glycolysis and cell growth of breast cancer through the regulation of p53 and mTOR signaling pathways Lavanya Ponnusamy and Ravi Manoharan BBA- Molecular cell Resarch 118975 2021 1
11 DAXX ameliorates metabolic dysfunction in mice with diet-induced obesity by activating the AMP-activated protein kinase-related kinase MPK38/MELK Hyun-A Seong and Ravi Manoharan contributed equally to this work Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha Biochemical and Biophysical Research Communications 1;572 2021 164-170
12 Palladium-mediated C–O bond activation of benzopyrone in 4-oxo-4H-chromone-3-carbaldehyde-4(N)-substituted thiosemicarbazone: synthesis, structure, nucleic acid/albumin interaction, DNA cleavage, antioxidant and cytotoxic studies A. Shanmugapriya, G. Kalaiarasi, M. Ravi, H. A. Sparkes, P. Kalaivanid and R. Prabhakaran New Journal of Chemistry 45 2021 20227-20240
13 MELK/MPK38 in cancer: from mechanistic aspects to therapeutic strategies. Karthik Thangaraj, Lavanya Ponnusamy, Sathan Raj Natarajan, and Ravi Manoharan Drug Discov Today 25 2020 30386
14 Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway. Lavanya Ponnusamy, Gugan Kothandan, and Ravi Manoharan Biochim Biophys Acta Mol Basis Dis 1866 2020 165897
15 Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions. Lavanya Ponnusamy, Sathan Raj Natarajan, Karthik Thangaraj, and Ravi Manoharan Biochim Biophys Acta Rev Cancer 1874 2020 188379
16 Understanding the dual mechanism of bioactive peptides targeting the enzymes involved in Renin Angiotensin System (RAS): An in-silico approach. Seshan G, Kanagasabai S, Jayanti B, Shantkriti S, Jaimohan S M , Ravi M, Sowmya R, Sekar K, and Gugan K. J Biomol Struct Dyn. 38 2020 5044-5061
17 Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. Cell Death Dis. 9 2018 471
18 Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development. Ravi Manoharan, Hyun-A Seong, and Hyunjung Ha. Oxid Med Cell Longev. 1 2018 5241524
19 Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways. Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. Sci Rep 7 2017 42502
20 Coordinate Activation of Redox-Dependent ASK1/TGF-β Signaling by a Multiprotein Complex (MPK38, ASK1, SMADs, ZPR9, and TRX) Improves Glucose and Lipid Metabolism in Mice. Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. Antioxid Redox Signal. 24 2016 434-52
21 A crucial role for the phosphorylation of STRAP at Ser (188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways. Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha. Cell Cycle. 13 2014 3357-74
22 Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner. Ravi Manoharan, Hyun-A Seong, and Hyunjung Ha. Free Radic Biol Med. 63 2013 313-24
23 PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity. Hyun-A Seong , Haiyoung Jung, Ravi Manoharan, and Hyunjung Ha. J Biol Chem. 287 2012 20811-22
24 Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein. Hyun-A Seong , Haiyoung Jung, Ravi Manoharan, and Hyunjung Ha. J Biol Chem. 286 2011 31123-35
25 B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction. Hyun-A Seong , Ravi Manoharan, and Hyunjung Ha Ha. J Biol Chem. 286 2011 7439-56
26 Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. Haiyoung Jung, Hyun-A Seong, Ravi Manoharan, and Hyunjung Ha. J Biol Chem. 285 2010 54-70
// FLASH NEWS //
  • University of Madras attains category - 1 status from UGC |  NIRF Ranking - Ranked 39 in University Category 2024 |  University of Madras has been graded A++ in the NAAC Assessment

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