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From the Desk of the Vice Chancellor

Greetings!

As the Vice Chancellor of this premier university, I am extremely pleased to share this space to converse with all of you. The University of Madras is a post- sesquicentennial institution which has forged a glorious path for itself and has been the site for significant scientific discoveries as well as the beacon for national and regional societal transformation. It has successfully managed to hold aloft its tradition even while keeping up with the emerging trends. One reason for this is the way in which the university has kept alive its interactions with all the stakeholders.

The COVID 19 pandemic has introduced a ‘new normal’ and its impact is felt in the workings of the university as well. The students have been attending the lectures online. While online learning has the advantage of being anytime and anywhere, it has taken away the peer group interaction and peer learning which are integral aspects of the university experience. We look forward to welcoming you to the campus very soon. Meanwhile, our faculty and administration will continue to bring the best to the virtual classrooms. As students, you need to view the restrictions posed by the pandemic as a temporary deterrent. Your focus should be to gain the competencies to conduct application oriented research in order to evolve as useful citizens of our society.

Our university boasts of faculty with a high degree of knowledge and commitment to offer the best in teaching and research. Given the context of the pandemic, we need to redefine our teaching-learning processes to offer the best pedagogic experience to our students. Similarly, the post-pandemic era demands that we hone the employment potential and entrepreneurial capacity of our learners. This necessitates that we focus on sponsored research in cutting edge areas.

Our administrative staff have been the backbone of the university. While we move towards a transparent and complete e-governance model, we need more support from you. When the teaching-learning process at our university – from admission to certification -- is moving into the digital era, your skills and competencies need to keep pace.

At our university, we are gearing up for the final round of NAAC re-accreditation. This has offered us an opportunity to assess our Strengths, Weaknesses, Opportunities and Challenges. Further, it has made us more determined to reiterate our quality benchmarks in teaching, research and extension activities. We are aware of this responsibility and fully prepared for it because, our university has always encouraged individual thinking within the established frameworks. This is echoed in the words of Tim Burners Lee, who initiated the World Wide Web: “We are forming cells within a global brain and we are excited that we might start to think collectively. What becomes of us still hangs crucially on how we think individually.” Let us unite to make the educational experience at the University of Madras a synergy of the best minds and best thoughts.

Prof.Dr.S.Gowri

Vice-Chancellor
University of Madras

Dr. G. SudhandiranM.Sc.,M.Phil., Ph.D

Professor
Department of Biochemistry
0

Awards

50

Publications

20

Seminars / Conference

8

Projects

26

Ph.D Awarded

1

Ph.D Present

Publications

Articles (Total Articles: 4)

# Title Author Publisher Volume Year Page(s)
1 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Sudhandiran G, et al Autophagy. 2021 Jan;17(1) 2021 1-382
2 Theranostic implications of heat shock proteins in idiopathic pulmonary fibrosisIn: Heat shock protein 90 in human diseases and disorders Sudhandiran G, Thomas D, Dineshbabu V, Soumyakrishnan S Ed. Alexzander Asea & Punit Kaur. Springer Nature v90 2019 493-506
3 Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review Ashokkumar, Divya T, Kalaivani K, Dinesh babu V, Velavan B, Sudhandiran G World J Gastrointest Oncol Sep 15, 2018; 10(9) 2018 244-259
4 Cell death and Disease : Meeting Report Sudhandiran G, Niranjali Devaraj S, Balasubramanyam M Cell death and Disease Current Science, 2015 1976-1977

Journals (Total Journals: 46)

# Title Author Publisher Volume Year Page(s)
1 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells Seetha A, Devaraj H, Sudhandiran G J Biochem Mol Toxicol e22 2020 433
2 Radical dendrimers: Synthesis, anti-tumor activity and enhanced cytoprotective performance of TEMPO free radical functionalized polyurethane dendrimers. Mohamad Ali B, Velavan B, Sudhandiran G, Sridevi J, Sultan Nasar A European Polymer Journal, 122 2020 109354
3 Combination of Juglone Along with Indomethacin Inhibits Proliferation and Alters Biochemical Parameters Against AOM/DSS “Induced Colon Carcinogenesis Without Gastric Ulceration In Balb/C Mice Seetha A, Devaraj H, Sudhandiran G. Int J of Adv Sci and Tech 29(6s) 2020 51 – 60
4 β-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1α/TGF-β/MMPs in A549 cells. Paneerselvam C, Ganapasam S. Toxicol Res (Camb). 2020 May 8;9(3) 2020 191-201
5 Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis. Dineshbabu V, Sureshkumar A, Sudhandiran G Drug Chem Toxicol. 2020 Sep 14 2020 1-12
6 Regulation of transforming growth factor beta/Smad mediated epithelial mesenchymal transition by Celastrol provides protection against Bleomycin Induced pulmonary fibrosis Divya T, Velavan B, Sudhandiran G Basic Clin Pharmacol Toxicol 123(2) 2018 122-129
7 Nano-chemotherapeutic efficacy of (-) -epigallocatechin 3-gallate mediating apoptosis in A549?cells: Involvement of reactive oxygen species mediated Nrf2/Keap1 signaling. Velavan B, Divya T, Sureshkumar A, Sudhandiran G Biochem Biophys Res Commun Sep 10;503(3) 2018 1723-1731
8 Role of proteases in regulating cell death pathways In: Pathophysiological aspects of Proteases Divya T, Vasudevan S, Sudhandiran G pringer Nature Publishers 535-551. 2017 13
9 Protease activated receptor signaling in lung pathologyIn: Pathophysiological aspects of Proteases Sudhandiran G, Kalayarasan S, Divya T, Velavan B Springer Nature publishers 567-581. 2017 15
10 Autophagy induction by Celastrol augments protection against bleomycin induced experimental pulmonary fiborsis in rats: Role of adaptor protein p62/SQSTM1 Divya T, Sureshkumar A, Sudhandiran G Pulm Pharmacol Ther 45 2017 47-61
11 Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits antifibrotic effect through regulation of collagen production against bleomycin induced pulmonary fibrosis Divya Thomas, Dinesh Babu V, Soumyakrishnan S, Sureshkumar A, Sudhandiran G Chem Biol Interact 246 2016 52-62
12 Genistein regulates tumor microenvironment and exhibits anticancer effect in dimethyl hydrazine-induced experimental colon carcinogenesis Vasudevan S, Sureskumar A, Sudhandiran G Chem Biol Interact 42(6) 2016 623-637
13 Carvacrol exhibits anti-oxidant and anti-inflammatory effects against 1,2, dimethylhydrazine plus dextran sodium sulfate induced inflammation associated carcinogenicity in the colon of Fisher 344 rats Arigesavan K, Sudhandiran G Biochem BioPhys Res Commun 461:2 2015 314-20
14 Farnesol attenuates lipopolysaccharide induced neurodegeneration in Swiss albino mice  by regulating intrinsic apoptotic cascade Santhana Sabapathy R, Sudhandiran G Brain Res 1620 2015 42-56
15 Protective effect of Naringin on 3-Nitropropionic acid induced neurodegeneration through the modulation of Matrix metalloproteinases and Glial fibrillary acidic protein Gopinath K, Sudhandiran G Can J Physiol Pharmacol 94(1) 2015 65-71
16 Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells Gopinath K, Sudhandiran G Mol Cell Biochem 409: 1-2 2015 199-211
17 Dietary flavonoid fisetin regulates Aluminum chloride induced neuronal apoptosis in cortex and hippocampus of mice brain J Nutr Biochem Prakash D, Sudhandiran G J Nutr Biochem 26(12) 2015 1527-1539
18 Farnesol quells oxidative stress, reactive gliosis and inflammation during Acrylamide induced neurotoxicity :  Behavioral and biochemical evidence Santhanasabapathy R, Vasudevan S, Anupriyakumari, Pabitha R, Sudhandiran G Neuroscience 12, 308 2015 212-227
19 XIAP inhibitor and antiestrogen embelin abbrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7  Sudhandiran G,Sumalatha KR, Abiramasundari G,Chetan GK, Mol Biol Rep 1-2. 2014 13
20 Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity. Prakash D, Gopinath K, Sudhandiran G Neuromolecular Med. 15 2013 192-208
21 Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2. Kalayarasan S, Sriram N, Soumyakrishnan S, Sudhandiran G Toxicol Appl Pharmacol 271 2013 184-195
22 Luteolin, a bioflavonoid, attenuates azoxymethane-induced effects on mitochondrial enzymes in BALB/c mice. Pandurangan AK, Ananda Sadagopan SK, Dharmalingam P, Sudhandiran G Asian Pac J Cancer Prev 14 2013 6669-6672
23 Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis Gopinath K, Prakash D, Sudhandiran G Neurochem Int. 59 2012 1066-1073
24 Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice. Pandurangan AK, Dharmalingam P, Anandasadagopan SK, Sudhandiran G Asian Pac J Cancer Prev 13 2012 1569-1573
25 Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats. Pandurangan AK, Periasamy S, Anandasadagopan SK, Sudhandiran G, Srinivasalu SD Asian Pac J Cancer Prev 13 2012 4107-4112
26 Ameliorating effect of fish oil on acrylamide induced oxidative stress and neuronal apoptosis in cerebral cortex. Lakshmi D, Gopinath K, Jayanthy G, Anjum S, Prakash D, Sudhandiran G Neurochem Res 37 2012 1859-1867.
27 Naringin modulates oxidative stress and inflammation in 3-NP induced neurodegeneration through activation of nuclear factor erythroid-2 related factor 2 signaling pathway. Gopinath K and Sudhandiran G Neuroscience 227 2012 134-143.
28 Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway.  Ume salma and Sudhandiran G Eur J Pharmacol 660 2011 249-258
29 Daidzein attenuates inflammation and exhibits antifibrotic effect against Bleomycin-induced pulmonary fibrosis in Wistar rats.   Soumyakrishnan S, Sudhandiran G. Biomed Prev Nutr 1 2011 236-244
30 Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Nagendraprabhu and Sudhandiran G Invest New Drugs 29 2010 207-224
31 Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ β-catenin pathway Ashokkumar and Sudhandiran G Invest New Drugs 29 2010 273-284
32 Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.  Umesalma S, Sudhandiran G. Basic Clin Pharmacol Toxicol. 107 2010 650-655
33 Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats Kalayarasan, Nagendra prabhu, Sriram N, Manikandan R., Arumugam M and Sudhandiran G Eur J Pharmacol 606 2009 162-171
34 Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis   through Nrf2–Keap1 signaling. Sriram N, Kalayarasan S and Sudhandiran G Pulm Pharmacol Ther 22 2009 221-236
35 Antioxidative and antiproliferative effects of astaxanthin during the initiation  stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis Nagendra prabhu, Ashok kumar and Sudhandiran G Fund Clin Pharmacol 23 2009 225-234
36 Epigallocatechin-3-gallate exhibits anti-fibrotic effect by attenuating bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in rat model pulmonary fibrosis Sriram N, Kalayarsan S and Sudhandiran G Chem Biol Inter 180 2009 271-280
37 Chemomodulation of the antioxidative enzymes and peroxidative damage in the colon of 1,2-dimethyl hydrazine induced rats by ellagic acid. Ume salma and Sudhandiran G Phytother Res 24 2009 S114-119
38 S-allylcysteine attenuates renal injury by altering the expressions of iNOS and matrix metallo proteinase-2 during cyclosporine-induced nephrotoxicity in Wistar rats. Magendiramani V, Umesalma S, Kalayarasan S, Nagendraprabhu P, Arunkumar J, Sudhandiran G J Appl Toxicol 29 2009 522-530
39 Enhancement of antioxidant defense system by epigallocatechin-3-gallate during bleomycin induced experimental pulmonary fibrosis Sriram N, Kalayarasan S and Sudhandiran G Biol Pharm Bull 31 2008 1306-1311
40 Protective role of Luteolin on the status of lipid peroxidation andantioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Ashokkumar and Sudhandiran G Biomedicine Pharmaco ther 62 2008 590-597
41 Diallyl sulfide induces apoptosis in colo 320 DM human colon cancer cells:  Involvement of caspase-3, NfkB, and ERK. Sriram N, Kalayarasan S, Ashok kumar P, Suresh kumar A and Sudhandiran G Mol Cell Biochem 311 2008 157-165
42 Diallyl sulfide attenuates bleomycin induced pulmonary fibrosis: critical role of iNOS, NFkB, TNF-α and IL-1β. Kalayarasan, Sriram and Sudhandiran G Life Sciences 82 2008 1142-1153
43 Chromium (VI)-induced oxidative stress and apoptosis is reduced by garlic and its derivative     S-allyl cysteine through the activation of Nrf2 in the hapatocytes of Wistar rats Kalayarasan, Sriram, Sureshkumar and Sudhandiran J Appl Toxicol 28 2008 908-919
44 Substrate specificity of the Leishmania donovani myo-inositol transporter:   Critical role of inositol C-2, C-3 and C-5 hydroxyl groups. Mongan TP, Sudhandiran G, Hobbs SB and Seyfang A Molecular and Biochemical Parasitology 135 2004 133-141
45 Antimonial induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani  amastigotes. Sudhandiran G and Shaha C Journal of Biological Chemistry 278 2003 25120-25132
46 Increase in cytosolic Calcium levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis like death in Leishmania donovani promastigotes.  SB Mukherjee, Das M, Sudhandiran G and Shaha C Journal of Biological Chemistry 277 2002 24717-24727
// FLASH NEWS //
  • University of Madras attains category - 1 status from UGC |  NIRF Ranking - Ranked 39 in University Category 2024 |  University of Madras has been graded A++ in the NAAC Assessment

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