Dr.V.Aravindhan

Assistant professor
Webpage : 
Specialization:

Diabetes,Tuberculosis, Filariasis, Immunology, Immunogenetics

Address:

Office: Dept of Genetics, Dr ALM PG IBMS, University of Madras Taramani, Chennai-600113. Fax: +91-44-2454070

Contact

Off: 044-24547060  Res: Nil

Mobile:

Office: cvaravindan@unom.ac.in

Other: cvaravindhan@gmail.com

Achievements

Membership

National
  • RESEARCH SOCIETY FOR THE STUDY OF DIABETES IN INDIA www.rssdi.in
  • INDIAN IMMUNOLOGY SOCIETY http://www.indianimmunology.org/

Projects (Total Projects : 5)

  • Title
    Role of Toll-Like Receptors (TLRs) in Diabetes and Tuberculosis (DM-TB) nexus (DST-FAST TRACK) SRF/FT/LS-105-2009
    Duration 2011-2014
    Funding Agency DST
    Amount Sanctioned (in Lakhs.) 16
  • Title
    Role of CD4+ T-Helper (Th) cells in Diabetes - Tuberculosis (DM-TB) Nexus 2012/37B/11/BRNS  
    Duration 2012-2015
    Funding Agency DAE
    Amount Sanctioned (in Lakhs.) 23
  • Title
    Screening for latent and active TB and impaired Mtb specific immune responses among Type-2 Diabetic subjects in the Chennai based clinic population 
    Duration 2016-2019
    Funding Agency DBT
    Amount Sanctioned (in Lakhs.) 4823800
  • Title
    Prediction of Treatment Failure among Diabetic Patients with Tuberculosis by Peripheral Blood Transcriptional Signature 
    Duration 2017-2020
    Funding Agency DBT
    Amount Sanctioned (in Lakhs.) 4805000
  • Title
    TLR induced secretion of α-defensin in type-2- diabetic subjects
    Duration 2016-2017
    Funding Agency Tamil Nadu State Research C
    Amount Sanctioned (in Lakhs.) 40000

Publications

Articles (Total Articles: 9)
  • Long term persistence of inflammation in children vaccinated with Salmonella conjugate vaccine is associated with augmented Th9-Th17 cytokine.,  Balaji C, Kevinkumar V, Aravindhan V.,  Cytokine,  91,  (2017),  128-131
  • Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes.,  Aravindhan V, Anand G.,  Am J Trop Med Hyg.,  97(6),  (2017),  1650-1661
  • Increased serum levels of novel T cell cytokines IL-33, IL-9 and IL-17 in subjects with type-1 diabetes.,  Shruthi S, Mohan V, Amutha A, Aravindhan V.,  Cytokine,  86,  (2016),  6-9
  • Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses.,  Aravindhan V, Madhumitha H.,  J Diabetes Res,  2016,  (2016),  6264149
  • Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic foot ulcer. ,  Dhamodharan U, Viswanathan V, Krishnamoorthy E, Rajaram R, Aravindhan V.,  Gene,  565(1),  (2015),  62-7
  • Impaired toll-like receptor signalling in peripheral B cells from newly diagnosed type-2 diabetic subjects.,  Madhumitha H, Mohan V, Kumar NP, Pradeepa R, Babu S, Aravindhan V.,  Cytokine,  76(2),  (2015),  253-259
  • Chronic Endotoxemia in Subjects with Type-1 Diabetes Is Seen Much before the Onset of Microvascular Complications.,  Aravindhan V, Mohan V, Arunkumar N, Sandhya S, Babu S.,  PLoS One,  10(9),  (2015),  e0137618
  • A Study on Longevity of Immune Response after Vaccination with Salmonella Typhi Vi Conjugate Vaccine (Pedatyph™) in Children. ,  Chinnasami B, Sadasivam K, Vivekanandhan A, Arunachalam P, Pasupathy S.,  J Clin Diagn Res.,  9(5),  (2015),  SC01-3
  • TLR-induced secretion of novel cytokine IL-27 is defective in newly diagnosed type-2 diabetic subjects.,  Madhumitha H, Mohan V, Babu S, Aravindhan V.,  Cytokine,  (1017), 

Journals (Total Journals: 19)

  • Serum IL-9, IL-17, and TGF-β levels in subjects with diabetic kidney disease (CURES-134). PMID:25542095,  Vasanthakumar R, Mohan V, Anand G, Deepa M., Babu S and Aravindhan V.*,  Cytokine,  72(1),  (2015, Mar),  109-12, 
  • Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease. PMID:24383855,  Madhumitha H, Mohan V, Deepa M, Babu S and Aravindhan V.*,  Cardiovascular Diabetology.,  13,  (2014 Jan 3),  1-8, 
  • Increased IL-12 and decreased IL-33 serum levels are associated with increased Th1 and suppressed Th2 cytokine profile in patients with diabetic nephropathy (CURES-134). PMID:25550844,  Anand G, Vasanthakumar R., Mohan V., Babu S. and Aravindhan V.*,  Int J Clin Exp Pathol,  7(11),  (2014),  8008-8015, 
  • Serum adiponectin helps to differentiate type 1 and type 2 diabetes among young asian indians. PMID:23902401,  Gokulakrishnan K, Aravindhan V, Amutha A, Abhijit S, Ranjani H, Anjana RM, Unnikrishnan R, Miranda P, Narayan KM, Mohan V.,  Diabetes Technol Ther.,  15 (8),  (2013 Aug),  696-702, 
  • Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121). PMID:22556082,  Aravindhan V*, Mohan V, Surendar J, Rao MM, Anuradha R, Deepa M, Babu S.,  Am J Trop Med Hyg.,  86(5),  (2012 May),  828-33, 
  • Increased levels of serum granulocyte-macrophage colony-stimulating factor is associated with activated peripheral dendritic cells in type 2 diabetes subjects (CURES-99).  PMID:22149626,  Surendar J, Mohan V, Pavankumar N, Babu S, Aravindhan V.*,  Diabetes Technol Ther.,  14(4),  (2012 Apr),  344-9, 
  • Circulating levels of high molecular weight (HMW) adiponectin and total adiponectin in relation to fat distribution, oxidative stress and inflammation in Asian Indians. PMID:22960344,  Indulekha K, Surendar J, Anjana RM, Gokulakrishnan K, Balasubramanyam M, Aravindhan V, Mohan V.,  Dis Markers.,  33(4),  (2012),  185-92, 
  • Increased levels of both Th1 and Th2 cytokines in subjects with metabolic syndrome (CURES-103). PMID:21355722,  Surendar J, Mohan V, Rao MM, Babu S, Aravindhan V.*,  Diabetes Technol Ther.,  13(4),  (2011 Apr),  477-82, 
  • Decreased serum interleukin-17 and increased transforming growth factor-β levels in subjects with metabolic syndrome (Chennai Urban Rural Epidemiology Study-95). PMID:20667562,  Surendar J, Aravindhan V*, Rao MM, Ganesan A, Mohan V.,  Metabolism.,  60(4),  (2011 Apr),  586-90, 
  • Association of cystatin-C with metabolic syndrome in normal glucose-tolerant subjects (CURES-97). PMID:20879967,  Surendar J, Indulekha K, Aravindhan V, Ganesan A, Mohan V.,  Diabetes Technol Ther.,  12(11),  (2010 Nov),  907-12, 
  • Decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (CURES 83). PMID:20559443,  Aravindhan V*, Mohan V, Surendar J, Muralidhara Rao M, Pavankumar N, Deepa M, Rajagopalan R, Kumaraswami V, Nutman TB, Babu S.,  PLoS Negl Trop Dis.,  4(6),  (2010 Jun 15),  e707, 
  • Decreased prevalence of lymphatic filariasis among subjects with type-1 diabetes. PMID:21118945,  Aravindhan V*, Mohan V, Surendar J, Rao MM, Ranjani H, Kumaraswami V, Nutman TB, Babu S.,  Am J Trop Med Hyg.,  83(6),  (2010 Dec),  1336-9, 
  • Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance (CURES-32). PMID:19419268,  Surendar J, Anuradha S, Ashley B, Balasubramanyam M, Aravindhan V, Rema M, Mohan V.,  Metab Syndr Relat Disord.,  7(5),  (2009 Oct),  419-25, 
  • Mycobacterium tuberculosis groE promoter controls the expression of the bicistronic groESL1 operon and shows differential regulation under stress conditions. PMID:19222581,  Aravindhan V, Christy AJ, Roy S, Ajitkumar P, Narayanan PR, Narayanan S.,  FEMS Microbiol Lett.,  292(1),  (2009 Mar),  42-9, 
  • Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines. PMID:18845682,  Zhu Q, Egelston C, Vivekanandhan A, Uematsu S, Akira S, Klinman DM, Belyakov IM, Berzofsky JA.,  Proc Natl Acad Sci U S A.,  105(42),  (2008 Oct 9.),  16260–16265, 
  • Identification & differentiation of Mycobacterium avium & M. intracellulare by PCR- RFLP assay using the groES gene. PMID:18219086,  Aravindhan V, Sulochana S, Narayanan S, Paramasivam CN, Narayanan PR.,  Indian J Med Res.,  126(6),  (2007 Dec),  575-9, 
  • T-h-2 immunity and CD3+CD45RBlow-activated T cells in mice immunized with recombinant bacillus Calmette-Guérin expressing HIV-1 principal neutralizing determinant epitope. PMID:16706787,  Aravindhan V, Narayanan S, Gautham N, Prasad V, Kannan P, Jacobs WR Jr, Narayanan P.,  FEMS Immunol Med Microbiol.,  47(1),  (2006 Jun),  45-55, 
  • In-vivo study on “Dual Signal Hypothesis” & its correlation to humoral immune response using mycobacterial antigen.,  Aravindhan V. and Sulochana Das.,  Current Science,  81(3),  (2001 Aug),  301-304, 
  •   Increased Levels of Endotoxin Core Antibodies and Decreased Levels of sCD 14 Indicate Chronic Endotoxemia in Coronary Artery Disease (CURES-127).,  Aravindhan V.*, Mohan V, Madhumitha H, Valarmathi S, Babu S,  J Clin Exp Cardiolog,  4,  (2013 July),  264, 

Seminar

National
  • Invited lecture at knowledge sharing forum, Sci – Gate on 30th May, 2013(Thursday) between 3.00pm to 4.00pm at ORCHID Research and Development Centre, Sholinganallur, Chennai.
  • Invited talk in National Conference on Current Research Perspectives in Biotechnology, Heathcare and Environment organized by Dept. of Biotechnology, Dr. M.G.R Educational & Research Institute Maduravoyal, Chennai - 600095. April 15th- 16th 2013.
  • Invited speaker at “VICENNIAL CELEBRATIONS” on 6 Feb  2014 at Post Graduate and Research Department of Biochemistry, Mohammad Sadak College of Arts and Science, Sholinganallur, Chennai-119  
  • Invited speaker at Immuno-bites 2013 on 19th June 2013 at Dept of oral&maxillofacial pathology SRM Dental college and hospital, Ramapuram, Chennai-89.
International
  • Invited key note speaker at 9th International science and maths symposium at California State University, Fullerton, USA (Mar 20th 2013). 

Guidance

Ph.D Awarded
Ph.D Students 4
M.Phil Awarded
M.Phil Students

Additional Informations

SCHOLARSHIP/FELLOWSHIP

  1. DST-DAAD Indo german visiting fellowship- Visitig Scientist at UKSH, Kiel, Germany (2017-2019)
  2. Visiting scientist at AIDS International Training & Research Programe (AITRP) at Albert Einstein College of Medicine, Yeshiva University, New York.
  3. Visiting Scientist at Seattle Biomedical Research Institute under Global Infectious Diseases Fellowship.  
  4. Oak Ridge Institute for Science and Education (ORISE) Fellowship- visiting researcher at NIH
  5. NET-UGC-CSIR Junior Research Fellowship (JRF) was awarded for clearing the National Level Eligibility Test Conducted by UGC-CSIR research Organizations.
  6. GATE Junior Research Fellowship (JRF) was offered for clearing the National Level Graduate aptitude test for Engineering (Life Sciences).
  7. University first at MSc Biomedical genetics (1999 University of Madras)
  8. Dr.Sanjeeva raj Memorial Book Grant Scholarship was awarded at Madras Christian College for academic performance in B.Sc.
INDUSTRIAL CONSULTANCY

1. Project title "Estimation serum anti-Vi antibody titers in children vaccinated with typhoid vaccine (Peda Typh)"- Dr.Balaji Chinnasamy, Department of Pediatrics, SRM Medical College Hospital & Research Centre, SRM Nagar, Potheri Village, Kattankulathur-603203 & M/s Bio-Med Private Limited, Ghaziabad-201009, U.P.