Dr. M. Arumugam

Webpage : 

Physiology and Biochemistry of Invertebrates ,Bio polymers with potential Biomedical Applications


Office: Professor & Head Department of Zoology University of Madras, Guindy Campus Chennai- 600 025


Off: 22202831  Res: Nil

Mobile: 91-94440-72927

Office: marumugam7@unom.ac.in

Other: marumugam7@hotmail.com


  • Govt of India  National Overseas Post-doctoral Fellowship (1989-90)
  • Govt. of India, Dept. of Biotechnology overseas Research Associateship (1999-2000)
  • Post Doctoral Fellow  Duke University Marine Laboratory, (1989-90) North Carolina, U.S.A.
  • Visiting Scientist  Department of Microbiology and  Immunology,  Duke Medical Centre, (1990 March & April) North Carolina, U.S.A.
  •  Department of Zoology, Oxford University, Oxford, U.K.(1989 March)
  •  Overseas Research Associate,  Defense et resistance invertebrate marins cc 080, University of Montpellier II Montpellier cedex 5, France (1999).
  • Institute fur Zoologie & Zoologishe    Museum, Universität Hamburg, Hamburg, Germany (2000).
  • Developed a P. G. Diploma in Immunotechnology and conducting in collaboration with Ms. Mediclone Biotech Pvt. Ltd., (A Biotech industry) successfully since 2005-06, (Achieved a placement record of 70 - 90 % of  students for the first time in Department of Zoology).
  • Developed a P. G. Diploma programme on MCB & SCT a unique programme for students who wish to persue research on Molecular cell biology and STEM CELL TECHNOLOGY, conducting in the Department of Zoology since 2002 – 2003.
  • As co-ordinator for Herbal Sciences Programme, the focused research area of University of Madras identified and  funded by University Grants Commission  (Rs. 107 Lakhs )  under University with Potentials for Excellence programme; Co-ordinating 54 research projects handled by faculty members of university; Created a world class laboratory and Instrumentation facility for herbal sciences research; Collaborating with 6 Pharmaceutical Industries in developing herbal drug products
  • Facilitated 10 patented herbal processes/products during 2006-07 under Herbal Sciences programme of U. G. C UPE programme
  • Facilitated   3 patents by the Department of Zoology including    one by self
  • Collaborating with Central Institute of Brackish water Aquaculture (CIBA) on developing and testing the efficacy of immunostimulants against WSSV – disease in shrimps
  • Collaborating with M/s. Mediclone Biotech pvt. Ltd., Chennai on “Mapping poison glands for snake venom toxin” funded by Department of Biotechnology Govt. of India


  •  Member, Board of Research Studies, University of Madras.  (Since March 2003 – 2010).
  • Chairman, Board of Studies in Zoology (PG), University of Madras (May 2003 – till date).
  • Co-ordinator, U.G.C - Special Assistance programme to Department  of  Zoology(2000 –  till date).
  • Co-ordinator, COSIST Assistance programme, UGC, New Delhi (2001 – 2006)
  •   Co-ordinator-University with Potential for Excellence, University of Madras (June 2003 – till date).
  • Programme Director, P. G. Diploma in Immunotechnology course conducted in  colloboration with Ms. Mediclone Biotech Pvt. Ltd
  •  Member of Senate and Academic Council, University of Madras

Projects (Total Projects : 5)

  • Title
    In vitro generation of reactive oxygen species and reactive nitrogen intermediates by the hemocytes of Macrobrachium rosenbergii
    Duration Completed, 2006
    Funding Agency University Grants C
    Amount Sanctioned (in Lakhs.) 8
  • Title
    Cytoprotective role of curcumin in selenium induced cataract formation in wistar rats.
    Duration Completed, 2008
    Funding Agency University Grants Commission, Herbal Science P
    Amount Sanctioned (in Lakhs.) 7
  • Title
    Immuno-responsive components in tiger shrimp 'Immuno-responsive components in tiger shrimp, Penaeus monodon, upon exposure to White Spot Syndrome Virus (WSSV) and immunostimulant.
    Duration 2009-2012
    Funding Agency Department of B
    Amount Sanctioned (in Lakhs.) 34
  • Title
    Studies on moult related changes in humoral and cellular immune responses in the mole crab, Emerita asiatica.
    Duration 2009-2012
    Funding Agency University Grants C
    Amount Sanctioned (in Lakhs.) 5
  • Title
    Studies on β-1,3 glucan binding protein (βGBP)-receptor mediated cellular immune response in the marine mussel Perna viridis
    Duration 2010-2013
    Funding Agency Department of Science and T
    Amount Sanctioned (in Lakhs.) 35


Papers (Total Papers: 16)
  • Effects of extract of soapnut Sapindus emarginatus on esterases and phosphatases of the vector mosquito, Aedes aegypti (Diptera: Culicidae).,  Koodalingam, A., P. Mullainadhan & M. Arumugam,  Acta Tropica,  118,  (2011),  27-36
  • Effect of curcumin on the modulation of αA- and αB- crystallin and heat shock protein 70 in selenium-induced cataractogenesis in Wistar rat pups.,  Manikandan R, Beulaja M, Thiagarajan R, Arumugam M,  Molecular Vision,  17,  (2011),  388-394
  • Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats.,  Manikandan R, Beulaja M, Thiagarajan R, Priyadarsini A, Saravanan R, Arumugam M.,  European Journal Pharmacology,  670(2-3),  (2011),  578-585
  • Curcumin prevents free radical mediated cataractogenesis through modulations in lens calcium. ,  Manikandan.,R., Thiagarajan, R., Beulaja S., Sudhandiran, G and M. Arumugam,  Free Radical Biology and Medicine,  15: 48(4),  (2010),  483-492
  • Effect of curcumin on selenium induced cataractogenesis in wistar rat pups,  Manikandan.,R., Thiagarajan, R., Beulaja S., Sudhandiran, G and M. Arumugam,  Current Eye Research,  35(2),  (2010),  122-129
  • Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats.,  Kalayarasan, S., Prabhu, P.N., Sriram, N., Manikandan, R., Arumugam, M & G. Sudhandiran,  European Journal of Pharmacology,  606,  (2009),  162-171
  • A antimosquito activity of aqueous kernel extract of soapnut Sapindus emarginatus: impact on various developmental stages of three vector mosquito species and non-target aquatic insects,  Koodalingam A., P. Mullainadhan & M. Arumugam,  Parasitology Research,  105,  (2009),  1425-1434
  • Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens.,  Manikandan, R., R. Thiagarajan, S. Beulaja , S. Chindhu, K. Mariammal, G. Sudhandiran, M. Arumugam,  Chemico-Biological Interactions,  181,  (2009),  202–209
  • Agglutinin mediated phagocytosis-associated generation of superoxide anion and nitric oxide by the hemocytes of the giant freshwater prawn Macrobrachium rosenbergii.,  Raman, T., M. Arumugam & P. Mullainadhan,  Fish and Shellfish Immunolgy,  24,  (2008),  337-345
  • Isolation, purification and characterisation of ß 1, 3-glucan binding protein from the marine mussel Perna viridis.,  Jayaraj, S. S., Thiagarajan, R., M. Arumugam & P. Mullainadhan,  Fish and Shellfish Immunolgy,  24,  (2008),  715-725
  • In Vitro generation of superoxide anion by hemocytes of Macrobrachium rosenbergii:  possible mechanism and pathways.,  Vidya. N., Thiyagarajan. R & M. Arumugam,  Journal of Experimental Zoology,  307 A,  (2007),  383 – 396
  • Isolation and characterization of an acetyl group-recognizing agglutinin from the serum of the Indian white shrimp, Feneropenaeus indicus,  Maheswari. R., P. Mullainadhan & M. Arumugam,  Archives of Biochemistry and Biophysics,  402,  (2002),  65-72
  • In vitro production of superoxide and nitric oxide (As nitrite and nitrate) by Mytilus gallprovincialis hemocytes upon incubation with PMA or laminarin or during yeast phagocytosis,  Arumugam. M., B. Romestand., J. Torreilles & P. Roch,  European Journal of Cell Biology,  79,  (2000),  513-519
  • Chloride masks effect of opposing positive charges in HbA and Hb-Hinsdale (b-139 Asn Lys) that can modulate cooperativity as well as oxygen affinity,  Bonaventura, C., M. Arumugam., R. Cashon., J. Bonaventura & W. F. Moo-Penn,  Journal of Molecular Biology,  239,  (1994),  561-568
  •  In vivo binding of exogeneous copper to hemolymph fractions of estuarine crab, Scylla serrata Forskal.,  Balaji, R., P. Mullainadhan & M. Arumugam,  Journal of Experimental Marine Biology and Ecology,  128,  (1989),  241-248
  • Significance of variation in haemolymph copper-protein ratio in the Scylla serrata Forskal during different hours of the day.,  Arumugam, M. & M. H. Ravindranath.,  Experientia,  36,  (1980),  1306-1307



Ph.D Awarded 9
Ph.D Students 7
M.Phil Awarded 19
M.Phil Students 1

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