Dr. S. Karthikeyan

Associate Professor & Head i/c
Webpage : 
Specialization:

Hepatotoxicology; Food Toxicology; Pharmacology and Toxicology;

Address:

Office: Department of Pharmacology and Environmental Toxicology Dr. ALM Post Graduate Institute of Basic Medical Sciences Sekkizhar Campus Taramani Chennai-113 University of Madras Taramani Campus, Chennai - 600 013

Contact

Off: 24547144  Res: 284463778

Mobile: 9444108748

Office: sivakarthikeyan@unom.ac.in

Other: karthi48y@yahoo.co.in , sivanesankarthikeyan@hotmail.com

Achievements

  • (i) Has received the SIRI Research Award - for best paper in Stress Physiology from  Annual Conference of Indian Association of Biomedical Scientists (ii) Has received the FABMS (Fellow of Indian Association of BioMedical Scientists) award from Indian Association of Biomedical Scientists (iii) Was invited by the Gulf Medical University, Ajman, UAE, as an Expert Committee Member to initiate M.Sc. Toxicology course in this University. (iv) Has published nearly 30 research papers in peer reviewed and indexed Inernational and National Journals. (v) Visiting Professor, Gulf Medical University, Ajman, UAE to deliver lectures for Master Degree students in Toxicology (vi) Has received funds for nearly 30 lakhs from UGC, DST and from industries to undertake Major Research Projects and consultancy projects in Hepatotoxicology, Environmental Toxicology, Drug Toxicology and Phytopharmacology. (vii) My Ph.D student Mr. D. Ezhilarasan was awarded the prestigious MAHEVA-MANDAMUS International Fellowship to undergo research work in Life scieces in the field of Liver toxicity in Brussels for 1 year from Oct. 2011 till June 2011. Earlier he received DST-INSPIRE Fellowship from DST, New Delhi. (viii) My student Mr. P.Vivekanandan received CSIR-SRF to undertake project work in hepatotoxicity

Membership

National
  • Life Member in Indian Association of Biomedical Scientist (Presently EC member and Treasurer of this Association)
  • Ordinary Member in Indian Pharmacological Society
  • Ordinary Member in Society of Toxicology (STOX), India

Projects (Total Projects : 5)

  • Title
    Studies on hepatoprotective and anti-oxidant properties of silymarin against antitubercular drugs induced hepatotoxicity in rats
    Duration 2005-2008
    Funding Agency DST, New D
    Amount Sanctioned (in Lakhs.) 12
  • Title
    Effect of mosquito coil smoke and mosquito mat vapour on antioxidants, microsomal enzymes, DNA damage in mice
    Duration 2004-2007
    Funding Agency UGC, New D
    Amount Sanctioned (in Lakhs.) 5
  • Title
      Effect of ethanolic leaf extract of Cassia fistula on antitubercular drugs and nitrosoamine induced hepatotoxicity in rats.
    Duration 2004-2008
    Funding Agency UPE, UNOM
    Amount Sanctioned (in Lakhs.) 4
  • Title
      Screeing for hepatoprotective and antioxidant properties of bioflavanoids against carbontetrachloride-induced hepatotoxicity in rats
    Duration 2007-2008
    Funding Agency EID, Parry (India) Ltd.
    Amount Sanctioned (in Lakhs.) 1
  • Title
    Food Toxicology, Liver toxicity.
    Duration
    Funding Agency Students Consultancy Proj
    Amount Sanctioned (in Lakhs.) 1

Publications

Papers (Total Papers: 25)
  • Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats. ,  Priya Sathish, Vijayalakshmi Paramasivam, Vivekandan Palani, Karthikeyan Sivanesan.,  Toxicol Indust Health,  (2012),  113-125
  • N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats. ,  Priya Sathish, Vijayalakshmi Paramasivam, Vivekandan Palani, Karthikeyan Sivanesan.,  Eur J Pharmacol,  654,  (2011),  181-186
  • Protective effect of Cassia fistula Linn. on diethylnitrosamine-induced hepatocellular damage and oxidative stress in ethanol pretreated rats.,  Kannampalli Pradeep, Chandrasekaran Victor Raj Mohan, Kupannan Gobianand and Sivanesan Karthikeyan.,  Biol Res.,  43,  (2010),  113-125
  • . Antiulcer activity of ethanol leaf extract of Cassia fistula. ,  Sivanesan Karthikeyan and Kuppannan Gobianand,  Pharmaceutical Biol.,  48 (8),  (2010),  869-877
  • Anti-inflammatory and antipyretic activities of Indian medicinal plant Cassia fistula Linn (Golden Shower) in wister albino rats.,  Gobianand K, Vivekanandan P, Pradeep K, Mohan CVR, Karthikeyan S.,  International. J Pharmacol,  6 (5),  (2010),  719-725
  • Evaluation of anti-bacterial, anti-fungal and anti-dermatophytic activities of different leaf extracts of Cassia fistula Linn. ,  Karthikeyan S and Gobianand K.,  Biomedicine,  29 (2),  (2009),  138-143
  • A time-course study on the onset of hepatotoxic, hyperlipidemic and oxidative stress effects of Isoniazid: modulation by Silymarin. ,  Vijayalakshmi P, Priya, S, Vivekanandan P and Karthikeyan S.,  Biomedicine,  28 (2),  (2008),  88-95
  • Effect of Casia fistula linn. leaf extract on diethylnitrosamine reduced hepatotoxicity in rats. ,  Pradeep.K., Victorraj Mohan.C., Gobianand.K. Karthikeyan.S.,  Chemico Biol. Int.,  167,  (2007),  12-18
  • Silymarin modulates the Oxidant-antioxidant imbalance during diethlynitrosamine induced Oxidative stress in rats.,  Pradeep.K., Victorraj Mohan.C., Gobianand.K. Karthikeyan.S.,  Eur J Pharmacol.,  560,  (2007),  110-116
  • Protective effect of silymarin against hydrazine-induced hyperlipidemia and helipidemia and hepatic steatosis in rats.,  Vivekanandan.P., Gobianand.K., Vijayalakshmi.P., Priya.S., Karthikeyan.S.,  Drug Chem Toxicol.,  30,  (2007),  1-12
  • Silymarin: An effective hepatoprotective agent against diethylnitrosamine-induced hepatotoxicity in rats. ,  Kannampalli Pradeep, Chandrasekaran Victor Raj Mohan, Kuppannan Gobianand, and Sivanesan Karthikeyan.,  Pharmaceutical Biology.,  45 (9),  (2007),  1-8
  •  Biochemical changes in serum lung, heart and spleen tissues of mice exposed to subacute toxic inhalation of mosquito repellant mat vapour”  ,  Karthikeyan S, Gobianand K, Pradeep K, Victor Raj Mohan C and Balasubramanian MP.,  J. Env. Biol.,  27 (2),  (2006),  355-358
  • Isoniazid an rifacpicin treatment on phaspholipids and there sub fractions in liver tissue of rabbits",  Karthikeyan.S.,  Drug Chem Toxicol.,  28,  (2005),  273-280
  • Influence of silymanrin administration on hepatic glutathion conjugating enzyme system in rats treated with antitubercular drugs.,  Victor raj Mohan. C., Pradeep.K., Karthikeyan.S.,  Drugs R & D.,  6 (6),  (2005),  395-400
  •  Effect of pretreatment of Cassia fistula Linn leaf extract against subacute CCl4 induced hepatotoxicity in rats. ,  Pradeep K, Victor Raj Mohan C, Gobianand K and Karthikeyan S.,  Ind. J. Exp. Biol.,  43,  (2005),  526-530
  • Hepatotoxicity of isoniazid: A study on the activity of marker enzymes of liver toxicity in serum and liver tissue of rabbits.,  Karthikeyan S.,  Ind. J. Pharmacol.,  36 (4),  (2004),  247-248
  • Effect of Mosquito coil smoke induced stress on the activity of transaminases and phosphatases in rats. ,  Karthikeyan S, Ezharasi Balasubramanian and Balasubramanian MP.,  J.Ecotoxicol. Environ. Monit.,  14 (2),  (2004),  111-117
  • Effect of mosquito coil smoke and mosquito repellant mat vapour on hematological parameters in mice.   ,  Karthikeyan S, Pradeep K, Victor Raj Mohan C and Gobianand. K.,  Geobios.,  30 (4),  (2003),  217-220
  • Isoniazid induced hepatic steatosis – an acute toxicity study in rabbits. ,  Karthikeyan S.,  Biomedicine,  22: (3&4),  (2003),  69-78
  • Studies on antibacterial activities of different extracts of Cassia fistula (Linn) leaves. ,  Gobianand K, Victor Raj Mohan C, Pradeep K and Karthikeyan S.,  Ind. Med. Homeop. J.,  2 (2),  (2002),  1-6
  • Effect of chronic administration of endosulfan on transaminases, alkaline phosphatase and protein in serum and liver of albino rats.  ,  Karthikeyan S.,  J. Ecotoxicol. Environ. Monit.,  11 (3),  (2001),  169-172
  • Effect of subacute administration of isoniazid and pyridoxine on lipids in plasma, liver and adipose tissues in the rabbit. ,  Karthikeyan S and Krishnamoorthy MS.,  Drug Chem. Toxicol.,  14 (3),  (1991),  293-303
  • Effect of Phenobarbital pretreatment on isoniazid induced lipid changes in plasma, liver and adipose tissues in the rabbit. ,  Krishnamoorthy MS and Karthikeyan S.,  Pharmacol. Res.,  24 (3),  (1991),  219-223
  • Biogenic amine status in acute fulminant hepatocellular failure in children. ,  Krishnamoorthy MS, Sundaravalli N, Soundar S and Karthikeyan S.,  Ind. J. Physiol. Pharmacol.,  33,  (1989),  15-20
  • Exchange transfusion and biogenic amine status in acute fulminant hepatocellular failure in children. ,  Krishnamoorthy MS, Sundaravalli N, Soundar S and Karthikeyan S.,  Ind. J. Pharmacol.,  22,  (1989),  97-102
Books (Total Books: 7)
  • Significance of risk assessment in aquatic toxicology. In: Risk Assessment – Basic Aspects. Maheswari SL. (ed.). Published by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-600 113.,  Karthikeyan S.,  (2003), ) 94-104, 
  • Experimental liver injury and toxic responses. In: Experimental Pharmacology and Toxicology. Venkatakrishna Murali R. (ed.). Published by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-600 113.,  Karthikeyan S.,  (2003), ) 89-98, 
  • Chlorination of drinking water and its toxicity in human and experimental animals. In: Toxicity Assessment of Aquatic Pollutants. Maheswari SL and Balasubramanian MP. (eds.). Published by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-113.,  Karthikeyan S.,  (2001), ) 47-62, 
  • Estimation of activity of phosphatases in serum. In: Techniques in Environmental Toxicology. Maheswari SL and Balasubramanian MP. (eds.). Published by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-113.,  Karthikeyan S.,  (2000), ) 25-30, 
  • Methods employed in the detection of adulterants in edible oils and fats. In: Techniques in Environmental Toxicology. Maheswari SL and Balasubramanian MP. (eds.). Published by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-113. ,  Karthikeyan S.,  (2000), ) 41-48, 
  • Methodologies employed to test liver functions in experimental animals. In: Biological Research Methadology. Edited by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-113.,  Karthikeyan S.,  (1999), ) 67-81, 
  • Transaminase assay in hepatotoxicity studies. In: Workshop manual on Toxicity Assessment of Environmental Pollutants. Edited by Dept. of Pharmacology and Environmental Toxicology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-113.,  Karthikeyan S.,  (1991), ) 47-54, 

Seminar

National
  • Karthikeyan S. Evidences for the hepatoprotective properties of ethanolic leaf extract of Cassia fistula Linn, the plant used in traditional systems of medicine. 31st Annual Conference of Indian Association of Biomedical Scientists and Symposium on Issues and Challenges of Traditional Systems of Medicine. October, 29th to 31st, 2010, held at Swamy Vivekanandha College of Pharmacy, Tiruchengode. Abstract No. SS-7.
  •   Ezhilarasan D. Vivekanandan P, Karthikeyan S. Alleviation of dimethylnitrosamine-induced oxidative stress and hepatic fibrosis by silibinin post treatment in rats. 31st Annual Conference of Indian Association of Biomedical Scientists and Symposium on Issues and Challenges of Traditional Systems of Medicine. October, 29th to 31st, 2010, held at Swamy Vivekanandha College of Pharmacy, Tiruchengode. Abstract No. SS-38. (Awarded First Prize for Best Poster Presentation in the above symposium)
  • Vivekanandan P, Priya S, Vijayalakshmi P and Karthikeyan S. Ameliorative effect of picroliv on hydrazine-induced hepatic steatosis in ethanol pre-treated rats. 30th Annual Conference of Indian Assiciation of Biomedical Scientists (IABMS), Defence Institute of High Altitude Research (DIHAR), Chandigarh, 18th to 20th November, 2009. Abstract No.PP-14, Pg. No.61-62.
  • Karthikeyan S, Vijayalakshmi P, Priya S, Vivekanandan P and Ezhilarasan D. Antitubercular drugs induced hepatic hecrosis and hyperlipidemia – mitigation of hepatic steatosis by silymarin and picroliv. 30th Annual Conference of Indian Assiciation of Biomedical Scientists (IABMS), Defence Institute of High Altitude Research (DIHAR), Chandigarh, 18th to 20th November, 2009. Abstract No.PP-15, Pg. No.62.
  • Ezhilarasan D, Karthikeyan S, Vijayalakshmi P, Priya S and Vivekanandan P. Silymarin protect liver against dimethylnitrosamine and ethanol-induced hepatic necrosis and oxidative stress in rats. 30th Annual Conference of Indian Assiciation of Biomedical Scientists (IABMS), Defence Institute of High Altitude Research (DIHAR), Chandigarh, 18th to 20th November, 2009. Abstract No.PP-16, Pg. No.63. – This paper received Best Poster Presentation price in the above conference.
  • Vivekanandan P, Ezhilarasan D, Priya S, Vijayalakshmi P and Karthikeyan S. Silymarin post treatment shows antilipidemic properties against ethanol plus hydrazine-induced hepatic steatosis in rats. XXIX Annual Conference of Society of Toxicology, India (STOX), 2009, Food and Drug Toxicology Research Centre, National Institute of Nutrition (NIN), Hyderabad, 4th to 7th November, 2009. Abstract No. FCPS-30, Pg. No. 107.
  • Karthikeyan S, Priya S, Vijayalakshmi P and Vivekanandan P. Evidence for the inhibition of acetyl hydrazine and hydrazine, the hepatotoxic metabolites of Isoniazid by Silymarin in antitubercular drugs treated rats. 29th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Ragas Dental College and Hospital, Chennai, 12th to 14th December, 2008. Abstract No.SP-9. Pg.no. 30-31.
  • Ezhilarasan D, Vijayalakshmi P, Vivekenandan P, Priya S and Karthikeyan S. Antitubercular drugs induced hepatic mitochondrial oxidative stress: protective role of Silymarin against toxicity. 29th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Ragas Dental College and Hospital, Chennai, 12th to 14th December, 2008. Abstract No.OP-46. Pg. no. 52-53.
  • Viayalakshmi P, Priya S, Vivekanandan S and Karthikeyan S. Isoniazid-induced hyperlipidemia and hepatic steatosis. Antilipidemic activity of Picroliv. 29th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Ragas Dental College and Hospital, Chennai, 12th to 14th December, 2008 Abstract No.OP-47.           Pg. no.53.
  • Vivekanandan S, Priya S, Vijayalakshmi P and Karthikeyan S. Modulatory role of Picroliv on the oxidant-antioxidant imbalance on hydrazine-induced oxidative stress in rat liver. 29th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Ragas Dental College and Hospital, Chennai, 12th to 14th December, 2008 Abstract No.OP-48. Pg.no. 54.
  • Vivekanandan P, Priya S, Vijayalakshmi P and Karthikeyan S. Modulatory role of Silymarin on hydrazine induced oxidative stress in rat liver. Annual conference of Southern Regional Indian Pharmacological Society, JIPMER, Pondicherry, 11th to 13th July, 2008. Abstract No. OP-11, Pg.no. 53.
  • Vijayalakshmi P, Priya S and Karthikeyan S. Comparative evaluation on the hepatoprotective and antilipidemic properties of Silymarin, Picroliv and Liv-52 against Isoniazid induced hepatic necrosis and steatosis in rats. National symposium on current Trends in the Development of Herbal Drugs and 27th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Thiruvananthapuram, 25 to 27th November, 2006; Abstract No.6, Pg.no. 131-132.
  • Vijayalakshmi P, Priya S and Karthikeyan S. Comparative evaluation on the hepatoprotective and antilipidemic properties of Silymarin, Picroliv and Liv-52 against Isoniazid induced hepatic necrosis and steatosis in rats. National symposium on current Trends in the Development of Herbal Drugs and 27th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Thiruvananthapuram, 25 to 27th November, 2006; Abstract No.6, Pg.no. 131-132.
  • Vijayalakshmi P, Priya S and Karthikeyan S. Comparative evaluation on the hepatoprotective and antilipidemic properties of Silymarin, Picroliv and Liv-52 against Isoniazid induced hepatic necrosis and steatosis in rats. National symposium on current Trends in the Development of Herbal Drugs and 27th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Thiruvananthapuram, 25 to 27th November, 2006; Abstract No.6, Pg.no. 131-132.
  • Priya S, Vijayalakshmi P and Karthikeyan S. Protective effects of Silymarin and n-acetylcysteine against dimethylnitrosamine-induced oxidative stress in rats. National symposium on current Trends in the Development of Herbal Drugs and 27th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Thiruvananthapuram, 25 to 27th November, 2006, Abstract No.3, Pg.no. 128-129
  • Vivenanandan P and Karthikeyan S. Antilipidemic potential of a single dose of Silymarin and Picroliv against hydrazine induced alterations in lipid profile in rats. National symposium on current Trends in the Development of Herbal Drugs and 27th Annual Conference of Indian Association of Biomedical Scientists (IABMS), Thiruvananthapuram, 25 to 27th November, 2006, Abstract No.7, Pg.no. 134-135.
International
  • Ezhilarasan D, Priya S, Vivekanandan P, Vijayalakshmi P and Karthikeyan S. Effect of n-acetylcysteine in ethanol plus DMN induced hepatotoxicity in rats. XXIX Annual Conference of Society of Toxicology, India (STOX), 2009, Food and Drug Toxicology Research Centre, National Institute of Nutrition (NIN), Hyderabad, 4th to 7th November, 2009. Abstract No. FCPS-9, Pg. No. 85.

Guidance

Ph.D Awarded 6
Ph.D Students 4
M.Phil Awarded 3
M.Phil Students 1

Additional Informations

Other Administrative duties

Warden, Barathidasan Post Graduate Hostel for Men, Sekkizhar Campus, Taramani, Chennai-113